Insights on the Structural Variations of the Furin-Like Cleavage Site Found Among the December 2019–July 2020 SARS-CoV-2 Spike Glycoprotein: A Computational Study Linking Viral Evolution and Infection

The SARS-CoV-2 (SARS2) is the cause of the coronavirus disease 2019 (COVID-19) pandemic. One unique structural feature of the SARS2 spike protein is the presence of a furin-like cleavage site (FLC) which is associated with both viral pathogenesis and host tropism. Specifically, SARS2 spike protein b...

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Detalles Bibliográficos
Autores principales: Cueno, Marni E., Ueno, Miu, Iguchi, Rinako, Harada, Tsubasa, Miki, Yoshifumi, Yasumaru, Kanae, Kiso, Natsumi, Wada, Kanta, Baba, Koki, Imai, Kenichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987684/
https://www.ncbi.nlm.nih.gov/pubmed/33777970
http://dx.doi.org/10.3389/fmed.2021.613412

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