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Natural Killer Cell Integrins and Their Functions in Tissue Residency

Integrins are transmembrane receptors associated with adhesion and migration and are often highly differentially expressed receptors amongst natural killer cell subsets in microenvironments. Tissue resident natural killer cells are frequently defined by their differential integrin expression compare...

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Detalles Bibliográficos
Autores principales: Shannon, Michael J., Mace, Emily M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987804/
https://www.ncbi.nlm.nih.gov/pubmed/33777044
http://dx.doi.org/10.3389/fimmu.2021.647358
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author Shannon, Michael J.
Mace, Emily M.
author_facet Shannon, Michael J.
Mace, Emily M.
author_sort Shannon, Michael J.
collection PubMed
description Integrins are transmembrane receptors associated with adhesion and migration and are often highly differentially expressed receptors amongst natural killer cell subsets in microenvironments. Tissue resident natural killer cells are frequently defined by their differential integrin expression compared to other NK cell subsets, and integrins can further localize tissue resident NK cells to tissue microenvironments. As such, integrins play important roles in both the phenotypic and functional identity of NK cell subsets. Here we review the expression of integrin subtypes on NK cells and NK cell subsets with the goal of better understanding how integrin selection can dictate tissue residency and mediate function from the nanoscale to the tissue environment.
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spelling pubmed-79878042021-03-25 Natural Killer Cell Integrins and Their Functions in Tissue Residency Shannon, Michael J. Mace, Emily M. Front Immunol Immunology Integrins are transmembrane receptors associated with adhesion and migration and are often highly differentially expressed receptors amongst natural killer cell subsets in microenvironments. Tissue resident natural killer cells are frequently defined by their differential integrin expression compared to other NK cell subsets, and integrins can further localize tissue resident NK cells to tissue microenvironments. As such, integrins play important roles in both the phenotypic and functional identity of NK cell subsets. Here we review the expression of integrin subtypes on NK cells and NK cell subsets with the goal of better understanding how integrin selection can dictate tissue residency and mediate function from the nanoscale to the tissue environment. Frontiers Media S.A. 2021-03-10 /pmc/articles/PMC7987804/ /pubmed/33777044 http://dx.doi.org/10.3389/fimmu.2021.647358 Text en Copyright © 2021 Shannon and Mace. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Shannon, Michael J.
Mace, Emily M.
Natural Killer Cell Integrins and Their Functions in Tissue Residency
title Natural Killer Cell Integrins and Their Functions in Tissue Residency
title_full Natural Killer Cell Integrins and Their Functions in Tissue Residency
title_fullStr Natural Killer Cell Integrins and Their Functions in Tissue Residency
title_full_unstemmed Natural Killer Cell Integrins and Their Functions in Tissue Residency
title_short Natural Killer Cell Integrins and Their Functions in Tissue Residency
title_sort natural killer cell integrins and their functions in tissue residency
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987804/
https://www.ncbi.nlm.nih.gov/pubmed/33777044
http://dx.doi.org/10.3389/fimmu.2021.647358
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