A Case Report of Central Nervous System Graft-Versus-Host Disease and Literature Review

As an adverse immune phenomenon, graft-versus-host disease often occurs after allogeneic hematopoietic stem cell transplantation. The incidence of acute and chronic graft-versus-host disease is about 40–60% and the mortality rate can reach 15%, which is a potentially fatal disease. There are rare Gv...

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Autores principales: Li, Mingming, Zhang, Yue, Guan, Yujia, Zhang, Zunwei, Dong, Hanbing, Zhao, Yang, Deng, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987907/
https://www.ncbi.nlm.nih.gov/pubmed/33776885
http://dx.doi.org/10.3389/fneur.2021.621392
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author Li, Mingming
Zhang, Yue
Guan, Yujia
Zhang, Zunwei
Dong, Hanbing
Zhao, Yang
Deng, Hui
author_facet Li, Mingming
Zhang, Yue
Guan, Yujia
Zhang, Zunwei
Dong, Hanbing
Zhao, Yang
Deng, Hui
author_sort Li, Mingming
collection PubMed
description As an adverse immune phenomenon, graft-versus-host disease often occurs after allogeneic hematopoietic stem cell transplantation. The incidence of acute and chronic graft-versus-host disease is about 40–60% and the mortality rate can reach 15%, which is a potentially fatal disease. There are rare GvHD cases involving the central nervous system. We reported a rare case of diffuse white matter changes after haploid bone marrow transplantation, summarizing its clinical manifestations and diagnosis and treatment in conjunction with the literature.
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spelling pubmed-79879072021-03-25 A Case Report of Central Nervous System Graft-Versus-Host Disease and Literature Review Li, Mingming Zhang, Yue Guan, Yujia Zhang, Zunwei Dong, Hanbing Zhao, Yang Deng, Hui Front Neurol Neurology As an adverse immune phenomenon, graft-versus-host disease often occurs after allogeneic hematopoietic stem cell transplantation. The incidence of acute and chronic graft-versus-host disease is about 40–60% and the mortality rate can reach 15%, which is a potentially fatal disease. There are rare GvHD cases involving the central nervous system. We reported a rare case of diffuse white matter changes after haploid bone marrow transplantation, summarizing its clinical manifestations and diagnosis and treatment in conjunction with the literature. Frontiers Media S.A. 2021-03-10 /pmc/articles/PMC7987907/ /pubmed/33776885 http://dx.doi.org/10.3389/fneur.2021.621392 Text en Copyright © 2021 Li, Zhang, Guan, Zhang, Dong, Zhao and Deng. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Li, Mingming
Zhang, Yue
Guan, Yujia
Zhang, Zunwei
Dong, Hanbing
Zhao, Yang
Deng, Hui
A Case Report of Central Nervous System Graft-Versus-Host Disease and Literature Review
title A Case Report of Central Nervous System Graft-Versus-Host Disease and Literature Review
title_full A Case Report of Central Nervous System Graft-Versus-Host Disease and Literature Review
title_fullStr A Case Report of Central Nervous System Graft-Versus-Host Disease and Literature Review
title_full_unstemmed A Case Report of Central Nervous System Graft-Versus-Host Disease and Literature Review
title_short A Case Report of Central Nervous System Graft-Versus-Host Disease and Literature Review
title_sort case report of central nervous system graft-versus-host disease and literature review
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987907/
https://www.ncbi.nlm.nih.gov/pubmed/33776885
http://dx.doi.org/10.3389/fneur.2021.621392
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