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Heart Enhancers: Development and Disease Control at a Distance
Bound by lineage-determining transcription factors and signaling effectors, enhancers play essential roles in controlling spatiotemporal gene expression profiles during development, homeostasis and disease. Recent synergistic advances in functional genomic technologies, combined with the development...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987942/ https://www.ncbi.nlm.nih.gov/pubmed/33777110 http://dx.doi.org/10.3389/fgene.2021.642975 |
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author | Yuan, Xuefei Scott, Ian C. Wilson, Michael D. |
author_facet | Yuan, Xuefei Scott, Ian C. Wilson, Michael D. |
author_sort | Yuan, Xuefei |
collection | PubMed |
description | Bound by lineage-determining transcription factors and signaling effectors, enhancers play essential roles in controlling spatiotemporal gene expression profiles during development, homeostasis and disease. Recent synergistic advances in functional genomic technologies, combined with the developmental biology toolbox, have resulted in unprecedented genome-wide annotation of heart enhancers and their target genes. Starting with early studies of vertebrate heart enhancers and ending with state-of-the-art genome-wide enhancer discovery and testing, we will review how studying heart enhancers in metazoan species has helped inform our understanding of cardiac development and disease. |
format | Online Article Text |
id | pubmed-7987942 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79879422021-03-25 Heart Enhancers: Development and Disease Control at a Distance Yuan, Xuefei Scott, Ian C. Wilson, Michael D. Front Genet Genetics Bound by lineage-determining transcription factors and signaling effectors, enhancers play essential roles in controlling spatiotemporal gene expression profiles during development, homeostasis and disease. Recent synergistic advances in functional genomic technologies, combined with the developmental biology toolbox, have resulted in unprecedented genome-wide annotation of heart enhancers and their target genes. Starting with early studies of vertebrate heart enhancers and ending with state-of-the-art genome-wide enhancer discovery and testing, we will review how studying heart enhancers in metazoan species has helped inform our understanding of cardiac development and disease. Frontiers Media S.A. 2021-03-10 /pmc/articles/PMC7987942/ /pubmed/33777110 http://dx.doi.org/10.3389/fgene.2021.642975 Text en Copyright © 2021 Yuan, Scott and Wilson. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Yuan, Xuefei Scott, Ian C. Wilson, Michael D. Heart Enhancers: Development and Disease Control at a Distance |
title | Heart Enhancers: Development and Disease Control at a Distance |
title_full | Heart Enhancers: Development and Disease Control at a Distance |
title_fullStr | Heart Enhancers: Development and Disease Control at a Distance |
title_full_unstemmed | Heart Enhancers: Development and Disease Control at a Distance |
title_short | Heart Enhancers: Development and Disease Control at a Distance |
title_sort | heart enhancers: development and disease control at a distance |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987942/ https://www.ncbi.nlm.nih.gov/pubmed/33777110 http://dx.doi.org/10.3389/fgene.2021.642975 |
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