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Heart Enhancers: Development and Disease Control at a Distance

Bound by lineage-determining transcription factors and signaling effectors, enhancers play essential roles in controlling spatiotemporal gene expression profiles during development, homeostasis and disease. Recent synergistic advances in functional genomic technologies, combined with the development...

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Detalles Bibliográficos
Autores principales: Yuan, Xuefei, Scott, Ian C., Wilson, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987942/
https://www.ncbi.nlm.nih.gov/pubmed/33777110
http://dx.doi.org/10.3389/fgene.2021.642975
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author Yuan, Xuefei
Scott, Ian C.
Wilson, Michael D.
author_facet Yuan, Xuefei
Scott, Ian C.
Wilson, Michael D.
author_sort Yuan, Xuefei
collection PubMed
description Bound by lineage-determining transcription factors and signaling effectors, enhancers play essential roles in controlling spatiotemporal gene expression profiles during development, homeostasis and disease. Recent synergistic advances in functional genomic technologies, combined with the developmental biology toolbox, have resulted in unprecedented genome-wide annotation of heart enhancers and their target genes. Starting with early studies of vertebrate heart enhancers and ending with state-of-the-art genome-wide enhancer discovery and testing, we will review how studying heart enhancers in metazoan species has helped inform our understanding of cardiac development and disease.
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spelling pubmed-79879422021-03-25 Heart Enhancers: Development and Disease Control at a Distance Yuan, Xuefei Scott, Ian C. Wilson, Michael D. Front Genet Genetics Bound by lineage-determining transcription factors and signaling effectors, enhancers play essential roles in controlling spatiotemporal gene expression profiles during development, homeostasis and disease. Recent synergistic advances in functional genomic technologies, combined with the developmental biology toolbox, have resulted in unprecedented genome-wide annotation of heart enhancers and their target genes. Starting with early studies of vertebrate heart enhancers and ending with state-of-the-art genome-wide enhancer discovery and testing, we will review how studying heart enhancers in metazoan species has helped inform our understanding of cardiac development and disease. Frontiers Media S.A. 2021-03-10 /pmc/articles/PMC7987942/ /pubmed/33777110 http://dx.doi.org/10.3389/fgene.2021.642975 Text en Copyright © 2021 Yuan, Scott and Wilson. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Yuan, Xuefei
Scott, Ian C.
Wilson, Michael D.
Heart Enhancers: Development and Disease Control at a Distance
title Heart Enhancers: Development and Disease Control at a Distance
title_full Heart Enhancers: Development and Disease Control at a Distance
title_fullStr Heart Enhancers: Development and Disease Control at a Distance
title_full_unstemmed Heart Enhancers: Development and Disease Control at a Distance
title_short Heart Enhancers: Development and Disease Control at a Distance
title_sort heart enhancers: development and disease control at a distance
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987942/
https://www.ncbi.nlm.nih.gov/pubmed/33777110
http://dx.doi.org/10.3389/fgene.2021.642975
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