CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation

Melanoma represents ~5% of all cutaneous malignancies, yet accounts for the majority of skin cancer deaths due to its propensity to metastasise. To develop new therapies, novel target molecules must to be identified and the accessibility of cell surface proteins makes them attractive targets. Using...

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Detalles Bibliográficos
Autores principales: van der Weyden, Louise, Harle, Victoria, Turner, Gemma, Offord, Victoria, Iyer, Vivek, Droop, Alastair, Swiatkowska, Agnieszka, Rabbie, Roy, Campbell, Andrew D., Sansom, Owen J., Pardo, Mercedes, Choudhary, Jyoti S., Ferreira, Ingrid, Tullett, Mark, Arends, Mark J., Speak, Anneliese O., Adams, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987976/
https://www.ncbi.nlm.nih.gov/pubmed/33758365
http://dx.doi.org/10.1038/s42003-021-01912-w

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