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Low-dose aspirin was associated with an increased risk of cardiovascular events in patients with chronic kidney disease and low bodyweight: results from KNOW-CKD study

The benefits and risks of aspirin therapy for patients with chronic kidney disease (CKD) who have a high burden of cardiovascular events (CVE) are controversial. To examine the effects of low-dose aspirin on major clinical outcomes in patients with CKD. As a prospective observational cohort study, u...

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Autores principales: Oh, Yun Jung, Kim, Ae Jin, Ro, Han, Chang, Jae Hyun, Lee, Hyun Hee, Chung, Wookyung, Hyun, Young Youl, Lee, Joongyub, Kim, Yeong Hoon, Han, Seung Hyeok, Chae, Dong-Wan, Ahn, Curie, Oh, Kook-Hwan, Jung, Ji Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988000/
https://www.ncbi.nlm.nih.gov/pubmed/33758303
http://dx.doi.org/10.1038/s41598-021-86192-4
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author Oh, Yun Jung
Kim, Ae Jin
Ro, Han
Chang, Jae Hyun
Lee, Hyun Hee
Chung, Wookyung
Hyun, Young Youl
Lee, Joongyub
Kim, Yeong Hoon
Han, Seung Hyeok
Chae, Dong-Wan
Ahn, Curie
Oh, Kook-Hwan
Jung, Ji Yong
author_facet Oh, Yun Jung
Kim, Ae Jin
Ro, Han
Chang, Jae Hyun
Lee, Hyun Hee
Chung, Wookyung
Hyun, Young Youl
Lee, Joongyub
Kim, Yeong Hoon
Han, Seung Hyeok
Chae, Dong-Wan
Ahn, Curie
Oh, Kook-Hwan
Jung, Ji Yong
author_sort Oh, Yun Jung
collection PubMed
description The benefits and risks of aspirin therapy for patients with chronic kidney disease (CKD) who have a high burden of cardiovascular events (CVE) are controversial. To examine the effects of low-dose aspirin on major clinical outcomes in patients with CKD. As a prospective observational cohort study, using propensity score matching, 531 aspirin recipients and non-recipients were paired for analysis from 2070 patients and fulfilled the inclusion criteria among 2238 patients with CKD. The primary outcome was the first occurrence of major CVE. The secondary outcomes were kidney events defined as a > 50% reduction of estimated glomerular filtration rate from baseline, doubling of serum creatinine, or onset of kidney failure with replacement therapy, the all-cause mortality, and bleeding event. The incidence of CVE was significantly greater in low-dose aspirin users than in non-users (HR 1.798; P = 0.011). A significant association between aspirin use and an increased risk of CVE was observed only in the lowest quartile of body weight (HR 4.014; P = 0.019) (Q1 < 60.0 kg). Secondary outcomes were not significantly different between aspirin users and non-users. It needs to be individualized of prescribing low-dose aspirin for the prevention of cardiovascular events in patients with chronic kidney disease, particularly patients with low bodyweight (< 60 kg).
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spelling pubmed-79880002021-03-25 Low-dose aspirin was associated with an increased risk of cardiovascular events in patients with chronic kidney disease and low bodyweight: results from KNOW-CKD study Oh, Yun Jung Kim, Ae Jin Ro, Han Chang, Jae Hyun Lee, Hyun Hee Chung, Wookyung Hyun, Young Youl Lee, Joongyub Kim, Yeong Hoon Han, Seung Hyeok Chae, Dong-Wan Ahn, Curie Oh, Kook-Hwan Jung, Ji Yong Sci Rep Article The benefits and risks of aspirin therapy for patients with chronic kidney disease (CKD) who have a high burden of cardiovascular events (CVE) are controversial. To examine the effects of low-dose aspirin on major clinical outcomes in patients with CKD. As a prospective observational cohort study, using propensity score matching, 531 aspirin recipients and non-recipients were paired for analysis from 2070 patients and fulfilled the inclusion criteria among 2238 patients with CKD. The primary outcome was the first occurrence of major CVE. The secondary outcomes were kidney events defined as a > 50% reduction of estimated glomerular filtration rate from baseline, doubling of serum creatinine, or onset of kidney failure with replacement therapy, the all-cause mortality, and bleeding event. The incidence of CVE was significantly greater in low-dose aspirin users than in non-users (HR 1.798; P = 0.011). A significant association between aspirin use and an increased risk of CVE was observed only in the lowest quartile of body weight (HR 4.014; P = 0.019) (Q1 < 60.0 kg). Secondary outcomes were not significantly different between aspirin users and non-users. It needs to be individualized of prescribing low-dose aspirin for the prevention of cardiovascular events in patients with chronic kidney disease, particularly patients with low bodyweight (< 60 kg). Nature Publishing Group UK 2021-03-23 /pmc/articles/PMC7988000/ /pubmed/33758303 http://dx.doi.org/10.1038/s41598-021-86192-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Oh, Yun Jung
Kim, Ae Jin
Ro, Han
Chang, Jae Hyun
Lee, Hyun Hee
Chung, Wookyung
Hyun, Young Youl
Lee, Joongyub
Kim, Yeong Hoon
Han, Seung Hyeok
Chae, Dong-Wan
Ahn, Curie
Oh, Kook-Hwan
Jung, Ji Yong
Low-dose aspirin was associated with an increased risk of cardiovascular events in patients with chronic kidney disease and low bodyweight: results from KNOW-CKD study
title Low-dose aspirin was associated with an increased risk of cardiovascular events in patients with chronic kidney disease and low bodyweight: results from KNOW-CKD study
title_full Low-dose aspirin was associated with an increased risk of cardiovascular events in patients with chronic kidney disease and low bodyweight: results from KNOW-CKD study
title_fullStr Low-dose aspirin was associated with an increased risk of cardiovascular events in patients with chronic kidney disease and low bodyweight: results from KNOW-CKD study
title_full_unstemmed Low-dose aspirin was associated with an increased risk of cardiovascular events in patients with chronic kidney disease and low bodyweight: results from KNOW-CKD study
title_short Low-dose aspirin was associated with an increased risk of cardiovascular events in patients with chronic kidney disease and low bodyweight: results from KNOW-CKD study
title_sort low-dose aspirin was associated with an increased risk of cardiovascular events in patients with chronic kidney disease and low bodyweight: results from know-ckd study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988000/
https://www.ncbi.nlm.nih.gov/pubmed/33758303
http://dx.doi.org/10.1038/s41598-021-86192-4
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