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NAC blocks Cystatin C amyloid complex aggregation in a cell system and in skin of HCCAA patients

Hereditary cystatin C amyloid angiopathy is a dominantly inherited disease caused by a leucine to glutamine variant of human cystatin C (hCC). L68Q-hCC forms amyloid deposits in brain arteries associated with micro-infarcts, leading ultimately to paralysis, dementia and death in young adults. To eva...

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Detalles Bibliográficos
Autores principales:	March, Michael E., Gutierrez-Uzquiza, Alvaro, Snorradottir, Asbjorg Osk, Matsuoka, Leticia S., Balvis, Noelia Fonseca, Gestsson, Thorgeir, Nguyen, Kenny, Sleiman, Patrick M. A., Kao, Charlly, Isaksson, Helgi J., Bragason, Birkir Thor, Olafsson, Elias, Palsdottir, Astridur, Hakonarson, Hakon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988011/ https://www.ncbi.nlm.nih.gov/pubmed/33758187 http://dx.doi.org/10.1038/s41467-021-22120-4

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