Cathepsin B and D deficiency in the mouse pancreas induces impaired autophagy and chronic pancreatitis

The major lysosomal proteases, Cathepsin B (CTSB), Cathepsin D (CTSD) and Cathepsin L (CTSL), are implicated in autophagic activity. To investigate the role of each cathepsin in the exocrine pancreas, we generated mice in which the pancreas was specifically deficient in Ctsb, Ctsd and Ctsl. Each of...

Descripción completa

Detalles Bibliográficos
Autores principales: Iwama, Hideaki, Mehanna, Sally, Imasaka, Mai, Hashidume, Shinsuke, Nishiura, Hiroshi, Yamamura, Ken-ichi, Suzuki, Chigure, Uchiyama, Yasuo, Hatano, Etsuro, Ohmuraya, Masaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988038/
https://www.ncbi.nlm.nih.gov/pubmed/33758261
http://dx.doi.org/10.1038/s41598-021-85898-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988038/
https://www.ncbi.nlm.nih.gov/pubmed/33758261
http://dx.doi.org/10.1038/s41598-021-85898-9

Ejemplares similares