Acitretin reverses early functional network degradation in a mouse model of familial Alzheimer’s disease

Aberrant activity of local functional networks underlies memory and cognition deficits in Alzheimer’s disease (AD). Hyperactivity was observed in microcircuits of mice AD-models showing plaques, and also recently in early stage AD mutants prior to amyloid deposition. However, early functional effect...

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Detalles Bibliográficos
Autores principales: Rosales Jubal, Eduardo, Schwalm, Miriam, dos Santos Guilherme, Malena, Schuck, Florian, Reinhardt, Sven, Tose, Amanda, Barger, Zeke, Roesler, Mona K., Ruffini, Nicolas, Wierczeiko, Anna, Schmeisser, Michael J., Schmitt, Ulrich, Endres, Kristina, Stroh, Albrecht
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988040/
https://www.ncbi.nlm.nih.gov/pubmed/33758244
http://dx.doi.org/10.1038/s41598-021-85912-0

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