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Multiwave pandemic dynamics explained: how to tame the next wave of infectious diseases

Pandemics, like the 1918 Spanish Influenza and COVID-19, spread through regions of the World in subsequent waves. Here we propose a consistent picture of the wave pattern based on the epidemic Renormalisation Group (eRG) framework, which is guided by the global symmetries of the system under time re...

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Autores principales: Cacciapaglia, Giacomo, Cot, Corentin, Sannino, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988059/
https://www.ncbi.nlm.nih.gov/pubmed/33758267
http://dx.doi.org/10.1038/s41598-021-85875-2
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author Cacciapaglia, Giacomo
Cot, Corentin
Sannino, Francesco
author_facet Cacciapaglia, Giacomo
Cot, Corentin
Sannino, Francesco
author_sort Cacciapaglia, Giacomo
collection PubMed
description Pandemics, like the 1918 Spanish Influenza and COVID-19, spread through regions of the World in subsequent waves. Here we propose a consistent picture of the wave pattern based on the epidemic Renormalisation Group (eRG) framework, which is guided by the global symmetries of the system under time rescaling. We show that the rate of spreading of the disease can be interpreted as a time-dilation symmetry, while the final stage of an epidemic episode corresponds to reaching a time scale-invariant state. We find that the endemic period between two waves is a sign of instability in the system, associated to near-breaking of the time scale-invariance. This phenomenon can be described in terms of an eRG model featuring complex fixed points. Our results demonstrate that the key to control the arrival of the next wave of a pandemic is in the strolling period in between waves, i.e. when the number of infections grows linearly. Thus, limiting the virus diffusion in this period is the most effective way to prevent or delay the arrival of the next wave. In this work we establish a new guiding principle for the formulation of mid-term governmental strategies to curb pandemics and avoid recurrent waves of infections, deleterious in terms of human life loss and economic damage.
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spelling pubmed-79880592021-03-25 Multiwave pandemic dynamics explained: how to tame the next wave of infectious diseases Cacciapaglia, Giacomo Cot, Corentin Sannino, Francesco Sci Rep Article Pandemics, like the 1918 Spanish Influenza and COVID-19, spread through regions of the World in subsequent waves. Here we propose a consistent picture of the wave pattern based on the epidemic Renormalisation Group (eRG) framework, which is guided by the global symmetries of the system under time rescaling. We show that the rate of spreading of the disease can be interpreted as a time-dilation symmetry, while the final stage of an epidemic episode corresponds to reaching a time scale-invariant state. We find that the endemic period between two waves is a sign of instability in the system, associated to near-breaking of the time scale-invariance. This phenomenon can be described in terms of an eRG model featuring complex fixed points. Our results demonstrate that the key to control the arrival of the next wave of a pandemic is in the strolling period in between waves, i.e. when the number of infections grows linearly. Thus, limiting the virus diffusion in this period is the most effective way to prevent or delay the arrival of the next wave. In this work we establish a new guiding principle for the formulation of mid-term governmental strategies to curb pandemics and avoid recurrent waves of infections, deleterious in terms of human life loss and economic damage. Nature Publishing Group UK 2021-03-23 /pmc/articles/PMC7988059/ /pubmed/33758267 http://dx.doi.org/10.1038/s41598-021-85875-2 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Cacciapaglia, Giacomo
Cot, Corentin
Sannino, Francesco
Multiwave pandemic dynamics explained: how to tame the next wave of infectious diseases
title Multiwave pandemic dynamics explained: how to tame the next wave of infectious diseases
title_full Multiwave pandemic dynamics explained: how to tame the next wave of infectious diseases
title_fullStr Multiwave pandemic dynamics explained: how to tame the next wave of infectious diseases
title_full_unstemmed Multiwave pandemic dynamics explained: how to tame the next wave of infectious diseases
title_short Multiwave pandemic dynamics explained: how to tame the next wave of infectious diseases
title_sort multiwave pandemic dynamics explained: how to tame the next wave of infectious diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988059/
https://www.ncbi.nlm.nih.gov/pubmed/33758267
http://dx.doi.org/10.1038/s41598-021-85875-2
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