CircRNA-Mediated Regulation of Angiogenesis: A New Chapter in Cancer Biology

Angiogenesis is necessary for carcinoma progression and is regulated by a variety of pro- and anti-angiogenesis factors. CircRNAs are RNA molecules that do not have a 5’-cap or a 3’-polyA tail and are involved in a variety of biological functions. While circRNA-mediated regulation of tumor angiogene...

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Autores principales: Jiang, Shaotao, Fu, Rongdang, Shi, Jiewei, Wu, Huijie, Mai, Jialuo, Hua, Xuefeng, Chen, Huan, Liu, Jie, Lu, Minqiang, Li, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988083/
https://www.ncbi.nlm.nih.gov/pubmed/33777729
http://dx.doi.org/10.3389/fonc.2021.553706
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author Jiang, Shaotao
Fu, Rongdang
Shi, Jiewei
Wu, Huijie
Mai, Jialuo
Hua, Xuefeng
Chen, Huan
Liu, Jie
Lu, Minqiang
Li, Ning
author_facet Jiang, Shaotao
Fu, Rongdang
Shi, Jiewei
Wu, Huijie
Mai, Jialuo
Hua, Xuefeng
Chen, Huan
Liu, Jie
Lu, Minqiang
Li, Ning
author_sort Jiang, Shaotao
collection PubMed
description Angiogenesis is necessary for carcinoma progression and is regulated by a variety of pro- and anti-angiogenesis factors. CircRNAs are RNA molecules that do not have a 5’-cap or a 3’-polyA tail and are involved in a variety of biological functions. While circRNA-mediated regulation of tumor angiogenesis has received much attention, the detailed biological regulatory mechanism remains unclear. In this review, we investigated circRNAs in tumor angiogenesis from multiple perspectives, including its upstream and downstream factors. We believe that circRNAs have natural advantages and great potential for the diagnosis and treatment of tumors, which deserves further exploration.
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spelling pubmed-79880832021-03-25 CircRNA-Mediated Regulation of Angiogenesis: A New Chapter in Cancer Biology Jiang, Shaotao Fu, Rongdang Shi, Jiewei Wu, Huijie Mai, Jialuo Hua, Xuefeng Chen, Huan Liu, Jie Lu, Minqiang Li, Ning Front Oncol Oncology Angiogenesis is necessary for carcinoma progression and is regulated by a variety of pro- and anti-angiogenesis factors. CircRNAs are RNA molecules that do not have a 5’-cap or a 3’-polyA tail and are involved in a variety of biological functions. While circRNA-mediated regulation of tumor angiogenesis has received much attention, the detailed biological regulatory mechanism remains unclear. In this review, we investigated circRNAs in tumor angiogenesis from multiple perspectives, including its upstream and downstream factors. We believe that circRNAs have natural advantages and great potential for the diagnosis and treatment of tumors, which deserves further exploration. Frontiers Media S.A. 2021-03-10 /pmc/articles/PMC7988083/ /pubmed/33777729 http://dx.doi.org/10.3389/fonc.2021.553706 Text en Copyright © 2021 Jiang, Fu, Shi, Wu, Mai, Hua, Chen, Liu, Lu and Li http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Jiang, Shaotao
Fu, Rongdang
Shi, Jiewei
Wu, Huijie
Mai, Jialuo
Hua, Xuefeng
Chen, Huan
Liu, Jie
Lu, Minqiang
Li, Ning
CircRNA-Mediated Regulation of Angiogenesis: A New Chapter in Cancer Biology
title CircRNA-Mediated Regulation of Angiogenesis: A New Chapter in Cancer Biology
title_full CircRNA-Mediated Regulation of Angiogenesis: A New Chapter in Cancer Biology
title_fullStr CircRNA-Mediated Regulation of Angiogenesis: A New Chapter in Cancer Biology
title_full_unstemmed CircRNA-Mediated Regulation of Angiogenesis: A New Chapter in Cancer Biology
title_short CircRNA-Mediated Regulation of Angiogenesis: A New Chapter in Cancer Biology
title_sort circrna-mediated regulation of angiogenesis: a new chapter in cancer biology
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988083/
https://www.ncbi.nlm.nih.gov/pubmed/33777729
http://dx.doi.org/10.3389/fonc.2021.553706
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