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Interferons: Tug of War Between Bacteria and Their Host

Type I and III interferons (IFNs) are archetypally antiviral cytokines that are induced in response to recognition of foreign material by pattern recognition receptors (PRRs). Though their roles in anti-viral immunity are well established, recent evidence suggests that they are also crucial mediator...

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Autores principales: Alphonse, Noémie, Dickenson, Ruth E., Odendall, Charlotte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988231/
https://www.ncbi.nlm.nih.gov/pubmed/33777837
http://dx.doi.org/10.3389/fcimb.2021.624094
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author Alphonse, Noémie
Dickenson, Ruth E.
Odendall, Charlotte
author_facet Alphonse, Noémie
Dickenson, Ruth E.
Odendall, Charlotte
author_sort Alphonse, Noémie
collection PubMed
description Type I and III interferons (IFNs) are archetypally antiviral cytokines that are induced in response to recognition of foreign material by pattern recognition receptors (PRRs). Though their roles in anti-viral immunity are well established, recent evidence suggests that they are also crucial mediators of inflammatory processes during bacterial infections. Type I and III IFNs restrict bacterial infection in vitro and in some in vivo contexts. IFNs mainly function through the induction of hundreds of IFN-stimulated genes (ISGs). These include PRRs and regulators of antimicrobial signaling pathways. Other ISGs directly restrict bacterial invasion or multiplication within host cells. As they regulate a diverse range of anti-bacterial host responses, IFNs are an attractive virulence target for bacterial pathogens. This review will discuss the current understanding of the bacterial effectors that manipulate the different stages of the host IFN response: IFN induction, downstream signaling pathways, and target ISGs.
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spelling pubmed-79882312021-03-25 Interferons: Tug of War Between Bacteria and Their Host Alphonse, Noémie Dickenson, Ruth E. Odendall, Charlotte Front Cell Infect Microbiol Cellular and Infection Microbiology Type I and III interferons (IFNs) are archetypally antiviral cytokines that are induced in response to recognition of foreign material by pattern recognition receptors (PRRs). Though their roles in anti-viral immunity are well established, recent evidence suggests that they are also crucial mediators of inflammatory processes during bacterial infections. Type I and III IFNs restrict bacterial infection in vitro and in some in vivo contexts. IFNs mainly function through the induction of hundreds of IFN-stimulated genes (ISGs). These include PRRs and regulators of antimicrobial signaling pathways. Other ISGs directly restrict bacterial invasion or multiplication within host cells. As they regulate a diverse range of anti-bacterial host responses, IFNs are an attractive virulence target for bacterial pathogens. This review will discuss the current understanding of the bacterial effectors that manipulate the different stages of the host IFN response: IFN induction, downstream signaling pathways, and target ISGs. Frontiers Media S.A. 2021-03-10 /pmc/articles/PMC7988231/ /pubmed/33777837 http://dx.doi.org/10.3389/fcimb.2021.624094 Text en Copyright © 2021 Alphonse, Dickenson and Odendall https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Alphonse, Noémie
Dickenson, Ruth E.
Odendall, Charlotte
Interferons: Tug of War Between Bacteria and Their Host
title Interferons: Tug of War Between Bacteria and Their Host
title_full Interferons: Tug of War Between Bacteria and Their Host
title_fullStr Interferons: Tug of War Between Bacteria and Their Host
title_full_unstemmed Interferons: Tug of War Between Bacteria and Their Host
title_short Interferons: Tug of War Between Bacteria and Their Host
title_sort interferons: tug of war between bacteria and their host
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988231/
https://www.ncbi.nlm.nih.gov/pubmed/33777837
http://dx.doi.org/10.3389/fcimb.2021.624094
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