Disease-linked supertrafficking of a potassium channel

Gain-of-function (GOF) mutations in the voltage-gated potassium channel subfamily Q member 1 (KCNQ1) can induce cardiac arrhythmia. In this study, it was tested whether any of the known human GOF disease mutations in KCNQ1 act by increasing the amount of KCNQ1 that reaches the cell surface—“supertra...

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Detalles Bibliográficos
Autores principales: Huang, Hui, Chamness, Laura M., Vanoye, Carlos G., Kuenze, Georg, Meiler, Jens, George, Alfred L., Schlebach, Jonathan Patrick, Sanders, Charles R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988323/
https://www.ncbi.nlm.nih.gov/pubmed/33600800
http://dx.doi.org/10.1016/j.jbc.2021.100423

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