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Liver cancer stem cells: Recent progress in basic and clinical research

The cancer stem cell (CSC) hypothesis was proposed over 4 decades ago and states that tumor growth is maintained by a small subset of cancer cells analogous to normal tissue stem cells in terms of self-renewal and differentiation capacity. Advances in CSC isolation were initially achieved in hematol...

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Detalles Bibliográficos
Autores principales: Yamashita, Taro, Kaneko, Shuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society for Regenerative Medicine 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988346/
https://www.ncbi.nlm.nih.gov/pubmed/33816720
http://dx.doi.org/10.1016/j.reth.2021.03.002
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author Yamashita, Taro
Kaneko, Shuichi
author_facet Yamashita, Taro
Kaneko, Shuichi
author_sort Yamashita, Taro
collection PubMed
description The cancer stem cell (CSC) hypothesis was proposed over 4 decades ago and states that tumor growth is maintained by a small subset of cancer cells analogous to normal tissue stem cells in terms of self-renewal and differentiation capacity. Advances in CSC isolation were initially achieved in hematological malignancies and later in solid tumors, including hepatocellular carcinoma (HCC), the major histological type of liver cancer. Increasing evidence suggests the importance of liver CSCs for tumor growth, metastasis, and chemo/radiation resistance in HCC, but the application of the liver CSC concept for the clinical diagnosis and treatment of HCC has not yet been achieved to the extent initially expected. Furthermore, the heterogeneity and plasticity of liver CSCs has recently been noted and might be related to drug resistance and the rapid growth and/or metastasis of the tumor after treatment. Here, we introduce our recent advancement in liver CSC research and discuss the clinical implications, which may lead to the development of improved diagnostics and treatment in HCC.
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spelling pubmed-79883462021-04-02 Liver cancer stem cells: Recent progress in basic and clinical research Yamashita, Taro Kaneko, Shuichi Regen Ther Review The cancer stem cell (CSC) hypothesis was proposed over 4 decades ago and states that tumor growth is maintained by a small subset of cancer cells analogous to normal tissue stem cells in terms of self-renewal and differentiation capacity. Advances in CSC isolation were initially achieved in hematological malignancies and later in solid tumors, including hepatocellular carcinoma (HCC), the major histological type of liver cancer. Increasing evidence suggests the importance of liver CSCs for tumor growth, metastasis, and chemo/radiation resistance in HCC, but the application of the liver CSC concept for the clinical diagnosis and treatment of HCC has not yet been achieved to the extent initially expected. Furthermore, the heterogeneity and plasticity of liver CSCs has recently been noted and might be related to drug resistance and the rapid growth and/or metastasis of the tumor after treatment. Here, we introduce our recent advancement in liver CSC research and discuss the clinical implications, which may lead to the development of improved diagnostics and treatment in HCC. Japanese Society for Regenerative Medicine 2021-03-21 /pmc/articles/PMC7988346/ /pubmed/33816720 http://dx.doi.org/10.1016/j.reth.2021.03.002 Text en © 2021 The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Yamashita, Taro
Kaneko, Shuichi
Liver cancer stem cells: Recent progress in basic and clinical research
title Liver cancer stem cells: Recent progress in basic and clinical research
title_full Liver cancer stem cells: Recent progress in basic and clinical research
title_fullStr Liver cancer stem cells: Recent progress in basic and clinical research
title_full_unstemmed Liver cancer stem cells: Recent progress in basic and clinical research
title_short Liver cancer stem cells: Recent progress in basic and clinical research
title_sort liver cancer stem cells: recent progress in basic and clinical research
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988346/
https://www.ncbi.nlm.nih.gov/pubmed/33816720
http://dx.doi.org/10.1016/j.reth.2021.03.002
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