Engineering of highly potent and selective HNTX-III mutant against hNa(v)1.7 sodium channel for treatment of pain

Human voltage-gated sodium channel Na(v)1.7 (hNa(v)1.7) is involved in the generation and conduction of neuropathic and nociceptive pain signals. Compelling genetic and preclinical studies have validated that hNa(v)1.7 is a therapeutic target for the treatment of pain; however, there is a dearth of...

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Detalles Bibliográficos
Autores principales: Zhang, Yunxiao, Wang, Li, Peng, Dezheng, Zhang, Qingfeng, Yang, Qiuchu, Li, Jiayan, Li, Dan, Tang, Dongfang, Chen, Minzhi, Liang, Songping, Liu, Yu, Wang, Sheng, Liu, Zhonghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988488/
https://www.ncbi.nlm.nih.gov/pubmed/33493520
http://dx.doi.org/10.1016/j.jbc.2021.100326

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