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Loss of O-GlcNAcase catalytic activity leads to defects in mouse embryogenesis

O-GlcNAcylation is an essential post-translational modification that has been implicated in neurodevelopmental and neurodegenerative disorders. O-GlcNAcase (OGA), the sole enzyme catalyzing the removal of O-GlcNAc from proteins, has emerged as a potential drug target. OGA consists of an N-terminal O...

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Detalles Bibliográficos
Autores principales:	Muha, Villő, Authier, Florence, Szoke-Kovacs, Zsombor, Johnson, Sara, Gallagher, Jennifer, McNeilly, Alison, McCrimmon, Rory J., Teboul, Lydia, van Aalten, Daan M.F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988489/ https://www.ncbi.nlm.nih.gov/pubmed/33610549 http://dx.doi.org/10.1016/j.jbc.2021.100439

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