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The transmembrane peptide DWORF activates SERCA2a via dual mechanisms

The Ca-ATPase isoform 2a (SERCA2a) pumps cytosolic Ca(2+) into the sarcoplasmic reticulum (SR) of cardiac myocytes, enabling muscle relaxation during diastole. Abnormally high cytosolic [Ca(2+)] is a central factor in heart failure, suggesting that augmentation of SERCA2a Ca(2+) transport activity c...

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Detalles Bibliográficos
Autores principales:	Li, Ang, Yuen, Samantha L., Stroik, Daniel R., Kleinboehl, Evan, Cornea, Razvan L., Thomas, David D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988493/ https://www.ncbi.nlm.nih.gov/pubmed/33581112 http://dx.doi.org/10.1016/j.jbc.2021.100412

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