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Structure and function of DEAH-box helicase 32 and its role in cancer
DEAH-box helicase 32 (DHX32) is an RNA helicase with unique structural characteristics that is involved in numerous biological processes associated with RNA, including ribosome biosynthesis, transcription, mRNA splicing and translation. Increasing evidence suggests that abnormal DHX32 expression con...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988694/ https://www.ncbi.nlm.nih.gov/pubmed/33777205 http://dx.doi.org/10.3892/ol.2021.12643 |
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author | Wei, Qingchun Geng, Jinting Chen, Yongquan Lin, Huayue Wang, Jiajia Fang, Zanxi Wang, Fen Zhang, Zhongying |
author_facet | Wei, Qingchun Geng, Jinting Chen, Yongquan Lin, Huayue Wang, Jiajia Fang, Zanxi Wang, Fen Zhang, Zhongying |
author_sort | Wei, Qingchun |
collection | PubMed |
description | DEAH-box helicase 32 (DHX32) is an RNA helicase with unique structural characteristics that is involved in numerous biological processes associated with RNA, including ribosome biosynthesis, transcription, mRNA splicing and translation. Increasing evidence suggests that abnormal DHX32 expression contributes to cancer initiation and development, due to dysregulated cell proliferation, differentiation, apoptosis and other processes. In the current review, the discovery, structure and function of DHX32, as well as the association between abnormal DHX32 expression and tumors are discussed. DHX32 expression is downregulated in acute lymphoblastic leukemia, but upregulated in solid tumors, including colorectal and breast cancer. Furthermore, DHX32 expression levels are associated with the pathological and clinical features of the cancer. Therefore, DHX32 may serve as a novel liquid biopsy marker for auxiliary diagnosis and prognosis screening, as well as a possible target for cancer therapy. The molecular mechanism underlying the contribution of DHX32 towards the initiation and development of cancer requires further investigation for the development of anticancer treatments based on manipulating DHX32 expression and function. |
format | Online Article Text |
id | pubmed-7988694 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-79886942021-03-26 Structure and function of DEAH-box helicase 32 and its role in cancer Wei, Qingchun Geng, Jinting Chen, Yongquan Lin, Huayue Wang, Jiajia Fang, Zanxi Wang, Fen Zhang, Zhongying Oncol Lett Review DEAH-box helicase 32 (DHX32) is an RNA helicase with unique structural characteristics that is involved in numerous biological processes associated with RNA, including ribosome biosynthesis, transcription, mRNA splicing and translation. Increasing evidence suggests that abnormal DHX32 expression contributes to cancer initiation and development, due to dysregulated cell proliferation, differentiation, apoptosis and other processes. In the current review, the discovery, structure and function of DHX32, as well as the association between abnormal DHX32 expression and tumors are discussed. DHX32 expression is downregulated in acute lymphoblastic leukemia, but upregulated in solid tumors, including colorectal and breast cancer. Furthermore, DHX32 expression levels are associated with the pathological and clinical features of the cancer. Therefore, DHX32 may serve as a novel liquid biopsy marker for auxiliary diagnosis and prognosis screening, as well as a possible target for cancer therapy. The molecular mechanism underlying the contribution of DHX32 towards the initiation and development of cancer requires further investigation for the development of anticancer treatments based on manipulating DHX32 expression and function. D.A. Spandidos 2021-05 2021-03-16 /pmc/articles/PMC7988694/ /pubmed/33777205 http://dx.doi.org/10.3892/ol.2021.12643 Text en Copyright: © Wei et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Review Wei, Qingchun Geng, Jinting Chen, Yongquan Lin, Huayue Wang, Jiajia Fang, Zanxi Wang, Fen Zhang, Zhongying Structure and function of DEAH-box helicase 32 and its role in cancer |
title | Structure and function of DEAH-box helicase 32 and its role in cancer |
title_full | Structure and function of DEAH-box helicase 32 and its role in cancer |
title_fullStr | Structure and function of DEAH-box helicase 32 and its role in cancer |
title_full_unstemmed | Structure and function of DEAH-box helicase 32 and its role in cancer |
title_short | Structure and function of DEAH-box helicase 32 and its role in cancer |
title_sort | structure and function of deah-box helicase 32 and its role in cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988694/ https://www.ncbi.nlm.nih.gov/pubmed/33777205 http://dx.doi.org/10.3892/ol.2021.12643 |
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