CACTUS: integrating clonal architecture with genomic clustering and transcriptome profiling of single tumor cells

BACKGROUND: Drawing genotype-to-phenotype maps in tumors is of paramount importance for understanding tumor heterogeneity. Assignment of single cells to their tumor clones of origin can be approached by matching the genotypes of the clones to the mutations found in RNA sequencing of the cells. The c...

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Detalles Bibliográficos
Autores principales: Shafighi, Shadi Darvish, Kiełbasa, Szymon M., Sepúlveda-Yáñez, Julieta, Monajemi, Ramin, Cats, Davy, Mei, Hailiang, Menafra, Roberta, Kloet, Susan, Veelken, Hendrik, van Bergen, Cornelis A.M., Szczurek, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988935/
https://www.ncbi.nlm.nih.gov/pubmed/33761980
http://dx.doi.org/10.1186/s13073-021-00842-w

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