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Mosquito‐repellent controlled‐release formulations for fighting infectious diseases

Malaria is a principal cause of illness and death in countries where the disease is endemic. Personal protection against mosquitoes using repellents could be a useful method that can reduce and/or prevent transmission of mosquito-borne diseases. The available repellent products, such as creams, roll...

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Autores principales: Mapossa, António B., Focke, Walter W., Tewo, Robert K., Androsch, René, Kruger, Taneshka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988998/
https://www.ncbi.nlm.nih.gov/pubmed/33761967
http://dx.doi.org/10.1186/s12936-021-03681-7
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author Mapossa, António B.
Focke, Walter W.
Tewo, Robert K.
Androsch, René
Kruger, Taneshka
author_facet Mapossa, António B.
Focke, Walter W.
Tewo, Robert K.
Androsch, René
Kruger, Taneshka
author_sort Mapossa, António B.
collection PubMed
description Malaria is a principal cause of illness and death in countries where the disease is endemic. Personal protection against mosquitoes using repellents could be a useful method that can reduce and/or prevent transmission of mosquito-borne diseases. The available repellent products, such as creams, roll-ons, and sprays for personal protection against mosquitoes, lack adequate long-term efficacy. In most cases, they need to be re-applied or replaced frequently. The encapsulation and release of the repellents from several matrices has risen as an alternative process for the development of invention of repellent based systems. The present work reviews various studies about the development and use of repellent controlled-release formulations such as polymer microcapsules, polymer microporous formulations, polymer micelles, nanoemulsions, solid-lipid nanoparticles, liposomes and cyclodextrins as new tools for mosquito-borne malaria control in the outdoor environment. Furthermore, investigation on the mathematical modelling used for the release rate of repellents is discussed in depth by exploring the Higuchi, Korsmeyer-Peppas, Weibull models, as well as the recently developed Mapossa model. Therefore, the studies searched suggest that the final repellents based-product should not only be effective against mosquito vectors of malaria parasites, but also reduce the biting frequency of other mosquitoes transmitting diseases, such as dengue fever, chikungunya, yellow fever and Zika virus. In this way, they will contribute to the improvement in overall public health and social well-being. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12936-021-03681-7.
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spelling pubmed-79889982021-03-25 Mosquito‐repellent controlled‐release formulations for fighting infectious diseases Mapossa, António B. Focke, Walter W. Tewo, Robert K. Androsch, René Kruger, Taneshka Malar J Review Malaria is a principal cause of illness and death in countries where the disease is endemic. Personal protection against mosquitoes using repellents could be a useful method that can reduce and/or prevent transmission of mosquito-borne diseases. The available repellent products, such as creams, roll-ons, and sprays for personal protection against mosquitoes, lack adequate long-term efficacy. In most cases, they need to be re-applied or replaced frequently. The encapsulation and release of the repellents from several matrices has risen as an alternative process for the development of invention of repellent based systems. The present work reviews various studies about the development and use of repellent controlled-release formulations such as polymer microcapsules, polymer microporous formulations, polymer micelles, nanoemulsions, solid-lipid nanoparticles, liposomes and cyclodextrins as new tools for mosquito-borne malaria control in the outdoor environment. Furthermore, investigation on the mathematical modelling used for the release rate of repellents is discussed in depth by exploring the Higuchi, Korsmeyer-Peppas, Weibull models, as well as the recently developed Mapossa model. Therefore, the studies searched suggest that the final repellents based-product should not only be effective against mosquito vectors of malaria parasites, but also reduce the biting frequency of other mosquitoes transmitting diseases, such as dengue fever, chikungunya, yellow fever and Zika virus. In this way, they will contribute to the improvement in overall public health and social well-being. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12936-021-03681-7. BioMed Central 2021-03-24 /pmc/articles/PMC7988998/ /pubmed/33761967 http://dx.doi.org/10.1186/s12936-021-03681-7 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Mapossa, António B.
Focke, Walter W.
Tewo, Robert K.
Androsch, René
Kruger, Taneshka
Mosquito‐repellent controlled‐release formulations for fighting infectious diseases
title Mosquito‐repellent controlled‐release formulations for fighting infectious diseases
title_full Mosquito‐repellent controlled‐release formulations for fighting infectious diseases
title_fullStr Mosquito‐repellent controlled‐release formulations for fighting infectious diseases
title_full_unstemmed Mosquito‐repellent controlled‐release formulations for fighting infectious diseases
title_short Mosquito‐repellent controlled‐release formulations for fighting infectious diseases
title_sort mosquito‐repellent controlled‐release formulations for fighting infectious diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988998/
https://www.ncbi.nlm.nih.gov/pubmed/33761967
http://dx.doi.org/10.1186/s12936-021-03681-7
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