Cargando…

Small-molecule HDAC and Akt inhibitors suppress tumor growth and enhance immunotherapy in multiple myeloma

BACKGROUND: Multiple myeloma (MM) is an incurable disease. The acquisition of resistance to drugs, including immunomodulatory drugs (IMiDs), has a negative effect on its prognosis. Cereblon (CRBN) is a key mediator of the bioactivities of IMiDs such as lenalidomide. Moreover, genetic alteration of C...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hirano, Mitsuhito, Imai, Yoichi, Kaito, Yuta, Murayama, Takahiko, Sato, Kota, Ishida, Tadao, Yamamoto, Junichi, Ito, Takumi, Futami, Muneyoshi, Ri, Masaki, Yasui, Hiroshi, Denda, Tamami, Tanaka, Yukihisa, Ota, Yasunori, Nojima, Masanori, Kamikubo, Yasuhiko, Gotoh, Noriko, Iida, Shinsuke, Handa, Hiroshi, Tojo, Arinobu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7989023/ https://www.ncbi.nlm.nih.gov/pubmed/33757580 http://dx.doi.org/10.1186/s13046-021-01909-7

Ejemplares similares

HDAC Inhibitors Exert Anti-Myeloma Effects through Multiple Modes of Action
por: Imai, Yoichi, et al.
Publicado: (2019)

CD155 and CD112 as possible therapeutic targets of FLT3 inhibitors for acute myeloid leukemia
por: Kaito, Yuta, et al.
Publicado: (2022)

Efficacy and Safety of Doubly-Regulated Vaccinia Virus in a Mouse Xenograft Model of Multiple Myeloma
por: Futami, Muneyoshi, et al.
Publicado: (2017)

The novel multi-cytokine inhibitor TO-207 specifically inhibits pro-inflammatory cytokine secretion in monocytes without affecting the killing ability of CAR T cells
por: Futami, Muneyoshi, et al.
Publicado: (2020)

CRISPR/Cas9 and AAV mediated insertion of β2 microglobulin-HLA-G fusion gene protects mesenchymal stromal cells from allogeneic rejection and potentiates the use for off-the-shelf cell therapy
por: Meshitsuka, Sohsuke, et al.
Publicado: (2022)

Treatment pattern and clinical outcomes in multiple myeloma patients in Japan using the Medical Data Vision claims database
por: Handa, Hiroshi, et al.
Publicado: (2023)

Case report: Common clonal origin of concurrent langerhans cell histiocytosis and acute myeloid leukemia
por: Kazama, Shintaro, et al.
Publicado: (2022)

Structural Basis for the Inhibition of Cyclin G‐Associated Kinase by Gefitinib
por: Ohbayashi, Naomi, et al.
Publicado: (2018)

Model of translational cancer research in multiple myeloma
por: Yasui, Hiroshi, et al.
Publicado: (2012)

Patient-Derived Xenograft Models of Breast Cancer and Their Application
por: Murayama, Takahiko, et al.
Publicado: (2019)

Drug resistance mechanisms of cancer stem-like cells and their therapeutic potential as drug targets
por: Murayama, Takahiko, et al.
Publicado: (2019)

Genetic compensation of RUNX family transcription factors in leukemia
por: Kamikubo, Yasuhiko
Publicado: (2018)

CROX (Cluster Regulation of RUNX) as a Potential Novel Therapeutic Approach
por: Kamikubo, Yasuhiko
Publicado: (2020)

A lung abscess caused by secondary syphilis – the utility of polymerase chain reaction techniques in transbronchial biopsy: a case report
por: Futami, Shinji, et al.
Publicado: (2019)

Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells
por: Tominaga, Kana, et al.
Publicado: (2019)

Proteomics of serum extracellular vesicles identifies a novel COPD biomarker, fibulin-3 from elastic fibres
por: Koba, Taro, et al.
Publicado: (2021)

Disseminated Tuberculosis with Cholecystitis in a Patient after Cord Blood Transplantation
por: Konuma, Takaaki, et al.
Publicado: (2020)

Langerhans cell histiocytosis in adults: Advances in pathophysiology and treatment
por: Kobayashi, Masayuki, et al.
Publicado: (2018)

Combining HDAC inhibitors with oncolytic virotherapy for cancer therapy
por: Nakashima, Hiroshi, et al.
Publicado: (2015)

An autocrine/paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of breast cancer stem-like cells
por: Sasahara, Asako, et al.
Publicado: (2017)

Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2
por: Nishimura, Tatsunori, et al.
Publicado: (2018)

Thiamine Deficiency and Neurological Symptoms in Patients with Hematological Cancer Receiving Chemotherapy: A Retrospective Analysis
por: Iimura, Yohei, et al.
Publicado: (2021)

Once-weekly vs. twice-weekly carfilzomib dosing in a subgroup of Japanese relapsed and refractory multiple myeloma patients from a randomized phase 3 trial (A.R.R.O.W.) and comparison with ENDEAVOR
por: Takezako, Naoki, et al.
Publicado: (2020)

ET-06 Suppression of glioblastoma through novel drug based on “Gene Switch Technology”
por: Yamamoto, Etsuko, et al.
Publicado: (2020)

Association Between Stroke and Metabolic Syndrome in a Japanese Population: Jichi Medical School (JMS) Cohort Study
por: Niwa, Yasunori, et al.
Publicado: (2010)

Metabolic Syndrome Mortality in a Population-Based Cohort Study: Jichi Medical School (JMS) Cohort Study
por: Niwa, Yasunori, et al.
Publicado: (2007)

DNA damage‐induced cellular senescence is regulated by 53BP1 accumulation in the nuclear foci and phase separation
por: Oda, Tsukasa, et al.
Publicado: (2023)

Hepatic Involvement of Histiocytic Sarcoma: CT and MRI Findings
por: Kubo, Takatoshi, et al.
Publicado: (2016)

Umbilical Cord-Derived Mesenchymal Stromal Cells Contribute to Neuroprotection in Neonatal Cortical Neurons Damaged by Oxygen-Glucose Deprivation
por: Mukai, Takeo, et al.
Publicado: (2018)

Mesenchymal stromal cells as a potential therapeutic for neurological disorders()
por: Mukai, Takeo, et al.
Publicado: (2018)

Elevated β-catenin pathway as a novel target for patients with resistance to EGF receptor targeting drugs
por: Nakata, Asuka, et al.
Publicado: (2015)

Loneliness, social isolation, and pain following the COVID-19 outbreak: data from a nationwide internet survey in Japan
por: Yamada, Keiko, et al.
Publicado: (2021)

Transient Antiphospholipid Syndrome Associated with Primary Cytomegalovirus Infection: A Case Report and Literature Review
por: Nakayama, Tsuyoshi, et al.
Publicado: (2014)

Expression of Histone Deacetylases HDAC1, HDAC2, HDAC3, and HDAC6 in Invasive Ductal Carcinomas of the Breast
por: Seo, Jinwon, et al.
Publicado: (2014)

Clinicopathological features and prediction values of HDAC1, HDAC2, HDAC3, and HDAC11 in classical Hodgkin lymphoma
por: Huang, Renhong, et al.
Publicado: (2018)

Correction: Genomic vulnerability to LINE-1 hypomethylation is a potential determinant of the clinicogenetic features of multiple myeloma
por: Aoki, Yuka, et al.
Publicado: (2013)

Genomic vulnerability to LINE-1 hypomethylation is a potential determinant of the clinicogenetic features of multiple myeloma
por: Aoki, Yuka, et al.
Publicado: (2012)

Calcification in original plaque and restenosis following carotid artery stenting
por: Katano, Hiroyuki, et al.
Publicado: (2017)

Dosing interval adjustment of denosumab for the treatment of giant cell tumor of the sphenoid bone: A case report
por: Tanikawa, Motoki, et al.
Publicado: (2020)

Efficient retroviral transduction of human B-lymphoid and myeloid progenitors: marked inhibition of their growth by the Pax5 transgene
por: Sekine, Rieko, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_9836agkpukvnhqsnsro4u8l9a4