Cargando…
The Use of Autologous Protein Solution (Pro-Stride(®)) and Leukocyte-Rich Platelet-Rich Plasma (Restigen(®)) in Canine Medicine
The use of autologous orthobiologics is an emerging area of interest in veterinary medicine. In this retrospective study, we reviewed the clinical results achieved using two orthobiologics devices to address orthopedic injuries and tissue repair. Leukocyte (White blood cell)-rich platelet-rich plasm...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7989049/ https://www.ncbi.nlm.nih.gov/pubmed/33777723 http://dx.doi.org/10.2147/VMRR.S286913 |
_version_ | 1783668883955122176 |
---|---|
author | King, William Cawood, Kevin Bookmiller, Megan |
author_facet | King, William Cawood, Kevin Bookmiller, Megan |
author_sort | King, William |
collection | PubMed |
description | The use of autologous orthobiologics is an emerging area of interest in veterinary medicine. In this retrospective study, we reviewed the clinical results achieved using two orthobiologics devices to address orthopedic injuries and tissue repair. Leukocyte (White blood cell)-rich platelet-rich plasma (L-PRP) devices produce outputs containing high concentrations of growth factors from venous blood. The Autologous Protein Solution (APS) device produces an orthobiologic containing high concentrations of growth factors and anti-inflammatory cytokines. L-PRP has commonly been used to address soft tissue injuries. APS has been injected into the joint to address osteoarthritis. In the last five years, our practice has treated 35 dogs (38 treatments) with L-PRP and 98 dogs (108 treatments) with APS. Our group has used L-PRP and APS to address orthopedic conditions including osteoarthritis, bursitis, tendinitis, tendon/ligament rupture/repair procedures, post-surgical femoral head osteotomy/tibial-plateau-leveling osteotomy tissue repair, lumbosacral stenosis, patellar luxation, joint laxity, and osteochondral dissecans. The results achieved with L-PRP and APS have been favorable (observed pain improvement and minimal adverse reactions), but sometimes have not achieved complete pain relief or tissue repair. The most common application for L-PRP was patellar luxation and the most common application for APS was injection post-ACL surgery. Canine OA has been successfully managed in several patients with repeat injections of APS over the course of several years. Future studies on specific conditions are ongoing and including efforts to further characterize these products in canine medicine. |
format | Online Article Text |
id | pubmed-7989049 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-79890492021-03-25 The Use of Autologous Protein Solution (Pro-Stride(®)) and Leukocyte-Rich Platelet-Rich Plasma (Restigen(®)) in Canine Medicine King, William Cawood, Kevin Bookmiller, Megan Vet Med (Auckl) Perspectives The use of autologous orthobiologics is an emerging area of interest in veterinary medicine. In this retrospective study, we reviewed the clinical results achieved using two orthobiologics devices to address orthopedic injuries and tissue repair. Leukocyte (White blood cell)-rich platelet-rich plasma (L-PRP) devices produce outputs containing high concentrations of growth factors from venous blood. The Autologous Protein Solution (APS) device produces an orthobiologic containing high concentrations of growth factors and anti-inflammatory cytokines. L-PRP has commonly been used to address soft tissue injuries. APS has been injected into the joint to address osteoarthritis. In the last five years, our practice has treated 35 dogs (38 treatments) with L-PRP and 98 dogs (108 treatments) with APS. Our group has used L-PRP and APS to address orthopedic conditions including osteoarthritis, bursitis, tendinitis, tendon/ligament rupture/repair procedures, post-surgical femoral head osteotomy/tibial-plateau-leveling osteotomy tissue repair, lumbosacral stenosis, patellar luxation, joint laxity, and osteochondral dissecans. The results achieved with L-PRP and APS have been favorable (observed pain improvement and minimal adverse reactions), but sometimes have not achieved complete pain relief or tissue repair. The most common application for L-PRP was patellar luxation and the most common application for APS was injection post-ACL surgery. Canine OA has been successfully managed in several patients with repeat injections of APS over the course of several years. Future studies on specific conditions are ongoing and including efforts to further characterize these products in canine medicine. Dove 2021-03-19 /pmc/articles/PMC7989049/ /pubmed/33777723 http://dx.doi.org/10.2147/VMRR.S286913 Text en © 2021 King et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Perspectives King, William Cawood, Kevin Bookmiller, Megan The Use of Autologous Protein Solution (Pro-Stride(®)) and Leukocyte-Rich Platelet-Rich Plasma (Restigen(®)) in Canine Medicine |
title | The Use of Autologous Protein Solution (Pro-Stride(®)) and Leukocyte-Rich Platelet-Rich Plasma (Restigen(®)) in Canine Medicine |
title_full | The Use of Autologous Protein Solution (Pro-Stride(®)) and Leukocyte-Rich Platelet-Rich Plasma (Restigen(®)) in Canine Medicine |
title_fullStr | The Use of Autologous Protein Solution (Pro-Stride(®)) and Leukocyte-Rich Platelet-Rich Plasma (Restigen(®)) in Canine Medicine |
title_full_unstemmed | The Use of Autologous Protein Solution (Pro-Stride(®)) and Leukocyte-Rich Platelet-Rich Plasma (Restigen(®)) in Canine Medicine |
title_short | The Use of Autologous Protein Solution (Pro-Stride(®)) and Leukocyte-Rich Platelet-Rich Plasma (Restigen(®)) in Canine Medicine |
title_sort | use of autologous protein solution (pro-stride(®)) and leukocyte-rich platelet-rich plasma (restigen(®)) in canine medicine |
topic | Perspectives |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7989049/ https://www.ncbi.nlm.nih.gov/pubmed/33777723 http://dx.doi.org/10.2147/VMRR.S286913 |
work_keys_str_mv | AT kingwilliam theuseofautologousproteinsolutionprostrideandleukocyterichplateletrichplasmarestigenincaninemedicine AT cawoodkevin theuseofautologousproteinsolutionprostrideandleukocyterichplateletrichplasmarestigenincaninemedicine AT bookmillermegan theuseofautologousproteinsolutionprostrideandleukocyterichplateletrichplasmarestigenincaninemedicine AT kingwilliam useofautologousproteinsolutionprostrideandleukocyterichplateletrichplasmarestigenincaninemedicine AT cawoodkevin useofautologousproteinsolutionprostrideandleukocyterichplateletrichplasmarestigenincaninemedicine AT bookmillermegan useofautologousproteinsolutionprostrideandleukocyterichplateletrichplasmarestigenincaninemedicine |