Cargando…

Alpha-1 antitrypsin (AAT) augmentation therapy in individuals with the PI*MZ genotype: a pro/con debate on a working hypothesis

Alpha-1 antitrypsin deficiency (AATD) is a significantly under-diagnosed genetic condition caused by reduced levels and/or functionality of alpha-1 antitrypsin (AAT), predisposing individuals to lung, liver or other systemic diseases. The management of individuals with the PI*MZ genotype, characteri...

Descripción completa

Detalles Bibliográficos
Autores principales:	Barjaktarevic, Igor, Miravitlles, Marc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7989144/ https://www.ncbi.nlm.nih.gov/pubmed/33757485 http://dx.doi.org/10.1186/s12890-021-01466-x

Ejemplares similares

Low Serum Alpha-1 Antitrypsin (AAT) in Family Members of Individuals with Autism Correlates with PiMZ Genotype
por: Russo, Anthony J., et al.
Publicado: (2009)

COPD in individuals with the PiMZ alpha-1 antitrypsin genotype
por: Al Ashry, Haitham S., et al.
Publicado: (2017)

Estimated Prevalence and Number of PiMZ Genotypes of Alpha-1 Antitrypsin in Seventy-Four Countries Worldwide
por: Martinez-González, Cristina, et al.
Publicado: (2021)

Hepatic decompensation is accelerated in patients with cirrhosis and alpha-1 antitrypsin Pi∗MZ genotype
por: Chen, Vincent L., et al.
Publicado: (2022)

Pulmonary transplantation of alpha-1 antitrypsin (AAT)-transgenic macrophages provides a source of functional human AAT in vivo
por: Janosz, Ewa, et al.
Publicado: (2021)

Alpha-1 Antitrypsin Z Variant (AAT PI*Z) as a Risk Factor for Intrahepatic Cholestasis of Pregnancy
por: Kosinski, Przemyslaw, et al.
Publicado: (2021)

Alpha(1)-Antitrypsin Deficiency: Transition of Care for the Child With AAT Deficiency into Adulthood
por: Lin, Henry C., et al.
Publicado: (2019)

Long Non-Coding RNA Expression in Alpha-1 Antitrypsin Deficient Monocytes Pre- and Post-AAT Augmentation Therapy
por: Smith, Stephen G. J., et al.
Publicado: (2023)

Alpha-1 antitrypsin Pi*Z gene frequency and Pi*ZZ genotype numbers worldwide: an update
por: Blanco, Ignacio, et al.
Publicado: (2017)

Alpha-1 Antitrypsin and Hepatocellular Carcinoma in Liver Cirrhosis: SERPINA1 MZ or MS Genotype Carriage Decreases the Risk
por: Rabekova, Zuzana, et al.
Publicado: (2021)

Why do some adults with PiMZ α(1)-antitrypsin develop bronchiectasis?
por: Aggarwal, Nupur, et al.
Publicado: (2016)

Alpha-1 antitrypsin Pi*SZ genotype: estimated prevalence and number of SZ subjects worldwide
por: Blanco, Ignacio, et al.
Publicado: (2017)

Augmentation therapy for alpha-1 antitrypsin deficiency: towards a personalised approach
por: Stockley, Robert A, et al.
Publicado: (2013)

Management of lung disease in alpha-1 antitrypsin deficiency: what we do and what we do not know
por: Barjaktarevic, Igor, et al.
Publicado: (2021)

Clinical considerations in individuals with α(1)-antitrypsin PI*SZ genotype
por: McElvaney, Gerard N., et al.
Publicado: (2020)

Safety and efficacy of alpha-1-antitrypsin augmentation therapy in the treatment of patients with alpha-1-antitrypsin deficiency
por: Petrache, Irina, et al.
Publicado: (2009)

Do MZ twins have discordant experiences of friendship? A qualitative hypothesis-generating MZ twin differences study
por: Asbury, Kathryn, et al.
Publicado: (2017)

Prevalence of α(1)-antitrypsin PiZZ genotypes in patients with COPD in Europe: a systematic review
por: Blanco, Ignacio, et al.
Publicado: (2020)

Correction: Do MZ twins have discordant experiences of friendship? A qualitative hypothesis-generating MZ twin differences study
por: Asbury, Kathryn, et al.
Publicado: (2017)

Alpha-1 antitrypsin genotypes in breast cancer patients
por: El-Akawi, Z, et al.
Publicado: (2005)

Hypothesis: Alpha-1-antitrypsin is a promising treatment option for COVID-19
por: Bai, Xiyuan, et al.
Publicado: (2021)

Human Alpha-1-Antitrypsin (hAAT) therapy reduces renal dysfunction and acute tubular necrosis in a murine model of bilateral kidney ischemia-reperfusion injury
por: Maicas, Nuria, et al.
Publicado: (2017)

Opinions and Attitudes of Pulmonologists About Augmentation Therapy in Patients with Alpha-1 Antitrypsin Deficiency. A Survey of the EARCO Group
por: Greulich, Timm, et al.
Publicado: (2022)

Development and results of the Spanish registry of patients with alpha-1-antitrypsin deficiency
por: Lara, Beatriz, et al.
Publicado: (2007)

Prevalence of PI*Z and PI*S alleles of alpha-1-antitrypsin deficiency in Finland
por: Häggblom, Jan, et al.
Publicado: (2015)

Feasibility of a genotyping system for the diagnosis of alpha1 antitrypsin deficiency: a multinational cross-sectional analysis
por: Lopez-Campos, José Luis, et al.
Publicado: (2022)

Survival in severe alpha-1-antitrypsin deficiency (PiZZ)
por: Tanash, Hanan A, et al.
Publicado: (2010)

Is PiSS Alpha-1 Antitrypsin Deficiency Associated with Disease?
por: McGee, Dawn, et al.
Publicado: (2010)

Sustained miRNA-mediated Knockdown of Mutant AAT With Simultaneous Augmentation of Wild-type AAT Has Minimal Effect on Global Liver miRNA Profiles
por: Mueller, Christian, et al.
Publicado: (2012)

Is an integrative laboratory algorithm more effective in detecting alpha-1-antitrypsin deficiency in patients with premature chronic obstructive pulmonary disease than AAT concentration based screening approach?
por: Beletic, Andjelo, et al.
Publicado: (2014)

Serum α-1 Antitrypsin (AAT) antagonizes intrinsic apoptosis induction in neutrophils from patients with systemic inflammatory response syndrome
por: Sarabhai, Theresia, et al.
Publicado: (2017)

Demographic and clinical characteristics of patients with α(1)-antitrypsin deficiency genotypes PI*ZZ and PI*SZ in the Spanish registry of EARCO
por: Torres-Durán, María, et al.
Publicado: (2022)

The $\Lambda$-parameter in 3-flavour QCD and $\alpha_s(m_Z)$ by the ALPHA collaboration
por: Bruno, M., et al.
Publicado: (2017)

Pro-Con Debate: Nitrous Oxide for Labor Analgesia
por: Vallejo, Manuel C., et al.
Publicado: (2019)

Direct measurement of alpha_QED(mZ)at the FCC-ee
por: Janot, Patrick
Publicado: (2015)

Reevaluation of the Hadronic Contributions to the Muon g-2 and to alpha(MZ)
por: Davier, Michel, et al.
Publicado: (2010)

Determination of $\alpha _s(m_Z)$ by the non-perturbative decoupling method
por: Dalla Brida, Mattia, et al.
Publicado: (2022)

Diagnosis of alpha-1 antitrypsin deficiency: a population-based study
por: Barrecheguren, Miriam, et al.
Publicado: (2016)

Thoracic Articles in AATS Journals
Publicado: (2022)

The prevalence of bronchiectasis in patients with alpha-1 antitrypsin deficiency: initial report of EARCO
por: Stockley, Robert A., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_qn8shv4agqf2tieq4gb12obpck