Neuronal cell-based high-throughput screen for enhancers of mitochondrial function reveals luteolin as a modulator of mitochondria-endoplasmic reticulum coupling

BACKGROUND: Mitochondrial dysfunction is a common feature of aging, neurodegeneration, and metabolic diseases. Hence, mitotherapeutics may be valuable disease modifiers for a large number of conditions. In this study, we have set up a large-scale screening platform for mitochondrial-based modulators...

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Detalles Bibliográficos
Autores principales: Naia, Luana, Pinho, Catarina M., Dentoni, Giacomo, Liu, Jianping, Leal, Nuno Santos, Ferreira, Duarte M. S., Schreiner, Bernadette, Filadi, Riccardo, Fão, Lígia, Connolly, Niamh M. C., Forsell, Pontus, Nordvall, Gunnar, Shimozawa, Makoto, Greotti, Elisa, Basso, Emy, Theurey, Pierre, Gioran, Anna, Joselin, Alvin, Arsenian-Henriksson, Marie, Nilsson, Per, Rego, A. Cristina, Ruas, Jorge L., Park, David, Bano, Daniele, Pizzo, Paola, Prehn, Jochen H. M., Ankarcrona, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7989211/
https://www.ncbi.nlm.nih.gov/pubmed/33761951
http://dx.doi.org/10.1186/s12915-021-00979-5

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