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PARTICULATE MATTER FROM SYRINGES USED FOR INTRAVITREAL INJECTIONS

Syringes containing anti-vascular endothelial growth factor drugs to treat retinal diseases are prepared in different ways by various parties with syringe selection, preparation, and storage conditions affecting the risk of injecting particles into the vitreous. This study examines particle loads fr...

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Autores principales: Dounce, Susan M., Laskina, Olga, Goldberg, Roger A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Retina 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7989597/
https://www.ncbi.nlm.nih.gov/pubmed/32956210
http://dx.doi.org/10.1097/IAE.0000000000002947
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author Dounce, Susan M.
Laskina, Olga
Goldberg, Roger A.
author_facet Dounce, Susan M.
Laskina, Olga
Goldberg, Roger A.
author_sort Dounce, Susan M.
collection PubMed
description Syringes containing anti-vascular endothelial growth factor drugs to treat retinal diseases are prepared in different ways by various parties with syringe selection, preparation, and storage conditions affecting the risk of injecting particles into the vitreous. This study examines particle loads from various syringes over time. METHODS: Four syringes were studied: two plastic transfer syringes lubricated with silicone oil or oleamide, a glass syringe with baked-on silicone, and a lubricant-free polymer syringe. Syringes were rinsed with water or filled with buffer and analyzed over time; particles were quantified by flow imaging. Particle formation in a bevacizumab formulation was also characterized. RESULTS: Insulin syringes consistently showed very high particle counts. Oleamide-lubricated syringes had substantially fewer particles, but showed appreciable increases over time (leading to visible particles). Baked-on silicone glass syringes and lubricant-free polymer syringes both showed low particle levels ≥10 μm. Lubricant-free syringes showed the lowest particle levels ≥1 μm and the lowest particle levels with bevacizumab agitation. CONCLUSION: Syringes have different intrinsic particle loads which can contribute to particle loads in the delivered drug. Oleamide-lubricated transfer syringes, commonly used for bevacizumab repackaging, have time-dependent particle loads and are associated with the formation of visible particles beyond 30 days of storage.
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spelling pubmed-79895972021-03-29 PARTICULATE MATTER FROM SYRINGES USED FOR INTRAVITREAL INJECTIONS Dounce, Susan M. Laskina, Olga Goldberg, Roger A. Retina Original Study Syringes containing anti-vascular endothelial growth factor drugs to treat retinal diseases are prepared in different ways by various parties with syringe selection, preparation, and storage conditions affecting the risk of injecting particles into the vitreous. This study examines particle loads from various syringes over time. METHODS: Four syringes were studied: two plastic transfer syringes lubricated with silicone oil or oleamide, a glass syringe with baked-on silicone, and a lubricant-free polymer syringe. Syringes were rinsed with water or filled with buffer and analyzed over time; particles were quantified by flow imaging. Particle formation in a bevacizumab formulation was also characterized. RESULTS: Insulin syringes consistently showed very high particle counts. Oleamide-lubricated syringes had substantially fewer particles, but showed appreciable increases over time (leading to visible particles). Baked-on silicone glass syringes and lubricant-free polymer syringes both showed low particle levels ≥10 μm. Lubricant-free syringes showed the lowest particle levels ≥1 μm and the lowest particle levels with bevacizumab agitation. CONCLUSION: Syringes have different intrinsic particle loads which can contribute to particle loads in the delivered drug. Oleamide-lubricated transfer syringes, commonly used for bevacizumab repackaging, have time-dependent particle loads and are associated with the formation of visible particles beyond 30 days of storage. Retina 2021-04 2020-09-21 /pmc/articles/PMC7989597/ /pubmed/32956210 http://dx.doi.org/10.1097/IAE.0000000000002947 Text en Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Opthalmic Communications Society, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Original Study
Dounce, Susan M.
Laskina, Olga
Goldberg, Roger A.
PARTICULATE MATTER FROM SYRINGES USED FOR INTRAVITREAL INJECTIONS
title PARTICULATE MATTER FROM SYRINGES USED FOR INTRAVITREAL INJECTIONS
title_full PARTICULATE MATTER FROM SYRINGES USED FOR INTRAVITREAL INJECTIONS
title_fullStr PARTICULATE MATTER FROM SYRINGES USED FOR INTRAVITREAL INJECTIONS
title_full_unstemmed PARTICULATE MATTER FROM SYRINGES USED FOR INTRAVITREAL INJECTIONS
title_short PARTICULATE MATTER FROM SYRINGES USED FOR INTRAVITREAL INJECTIONS
title_sort particulate matter from syringes used for intravitreal injections
topic Original Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7989597/
https://www.ncbi.nlm.nih.gov/pubmed/32956210
http://dx.doi.org/10.1097/IAE.0000000000002947
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