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Monocyte-to-Lymphocyte Ratio is Associated with Depression 3 Months After Stroke

PURPOSE: To explore the relationship between the monocyte-to-lymphocyte ratio (MLR) and depression three months after acute ischemic stroke. PATIENTS AND METHODS: From May 2013 to September 2014, 203 patients with acute ischemic stroke were recruited within 7 days post-stroke from Shanghai Ruijin Ho...

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Autores principales: Ding, Kai-qi, Lai, Ze-hua, Zhang, Yu, Yang, Guo-yuan, He, Ji-rong, Zeng, Li-li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7989958/
https://www.ncbi.nlm.nih.gov/pubmed/33776439
http://dx.doi.org/10.2147/NDT.S299462
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author Ding, Kai-qi
Lai, Ze-hua
Zhang, Yu
Yang, Guo-yuan
He, Ji-rong
Zeng, Li-li
author_facet Ding, Kai-qi
Lai, Ze-hua
Zhang, Yu
Yang, Guo-yuan
He, Ji-rong
Zeng, Li-li
author_sort Ding, Kai-qi
collection PubMed
description PURPOSE: To explore the relationship between the monocyte-to-lymphocyte ratio (MLR) and depression three months after acute ischemic stroke. PATIENTS AND METHODS: From May 2013 to September 2014, 203 patients with acute ischemic stroke were recruited within 7 days post-stroke from Shanghai Ruijin Hospital and blood samples were collected after admission. The Hamilton Depression Scale and Clinical Review were evaluated at 3 months after stroke. Based on the Diagnostic and Statistical Manual of Mental Disorders-IV diagnostic criteria, we divided patients into post-stroke depression (PSD) and non-PSD groups. We analyzed the intergroup difference in MLR and the contributing factors. Moreover, dynamic changes in monocytes, lymphocytes and MLR at four different time intervals for all the stroke patients and their relationship with PSD patients were also studied. RESULTS: The NIHSS scores and MLR in the PSD group were significantly higher than in the non-PSD group (p<0.05). Logistic regression analysis revealed MLR was an independent risk factor for PSD (odds ratio: 18.020, 95% confidence interval: 1.127‒288.195, p=0.041). MLR correlated negatively with cholesterol and low-density lipoprotein (r=−0.160 and −0.165, respectively, p<0.05). Within 7 days post-acute ischemic stroke, monocytes gradually increased while lymphocytes remained unchanged for all the stroke patients. The MLR value was significantly higher in the PSD group than in the non-PSD group within 24 h post-stroke (p<0.05), but there was no difference in the other three time-intervals between the two groups. CONCLUSION: The admission MLR, particularly within 24 h post-stroke, was associated with PSD at 3 months, implying that the MLR might be involved in the PSD inflammatory mechanism.
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spelling pubmed-79899582021-03-25 Monocyte-to-Lymphocyte Ratio is Associated with Depression 3 Months After Stroke Ding, Kai-qi Lai, Ze-hua Zhang, Yu Yang, Guo-yuan He, Ji-rong Zeng, Li-li Neuropsychiatr Dis Treat Original Research PURPOSE: To explore the relationship between the monocyte-to-lymphocyte ratio (MLR) and depression three months after acute ischemic stroke. PATIENTS AND METHODS: From May 2013 to September 2014, 203 patients with acute ischemic stroke were recruited within 7 days post-stroke from Shanghai Ruijin Hospital and blood samples were collected after admission. The Hamilton Depression Scale and Clinical Review were evaluated at 3 months after stroke. Based on the Diagnostic and Statistical Manual of Mental Disorders-IV diagnostic criteria, we divided patients into post-stroke depression (PSD) and non-PSD groups. We analyzed the intergroup difference in MLR and the contributing factors. Moreover, dynamic changes in monocytes, lymphocytes and MLR at four different time intervals for all the stroke patients and their relationship with PSD patients were also studied. RESULTS: The NIHSS scores and MLR in the PSD group were significantly higher than in the non-PSD group (p<0.05). Logistic regression analysis revealed MLR was an independent risk factor for PSD (odds ratio: 18.020, 95% confidence interval: 1.127‒288.195, p=0.041). MLR correlated negatively with cholesterol and low-density lipoprotein (r=−0.160 and −0.165, respectively, p<0.05). Within 7 days post-acute ischemic stroke, monocytes gradually increased while lymphocytes remained unchanged for all the stroke patients. The MLR value was significantly higher in the PSD group than in the non-PSD group within 24 h post-stroke (p<0.05), but there was no difference in the other three time-intervals between the two groups. CONCLUSION: The admission MLR, particularly within 24 h post-stroke, was associated with PSD at 3 months, implying that the MLR might be involved in the PSD inflammatory mechanism. Dove 2021-03-19 /pmc/articles/PMC7989958/ /pubmed/33776439 http://dx.doi.org/10.2147/NDT.S299462 Text en © 2021 Ding et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Ding, Kai-qi
Lai, Ze-hua
Zhang, Yu
Yang, Guo-yuan
He, Ji-rong
Zeng, Li-li
Monocyte-to-Lymphocyte Ratio is Associated with Depression 3 Months After Stroke
title Monocyte-to-Lymphocyte Ratio is Associated with Depression 3 Months After Stroke
title_full Monocyte-to-Lymphocyte Ratio is Associated with Depression 3 Months After Stroke
title_fullStr Monocyte-to-Lymphocyte Ratio is Associated with Depression 3 Months After Stroke
title_full_unstemmed Monocyte-to-Lymphocyte Ratio is Associated with Depression 3 Months After Stroke
title_short Monocyte-to-Lymphocyte Ratio is Associated with Depression 3 Months After Stroke
title_sort monocyte-to-lymphocyte ratio is associated with depression 3 months after stroke
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7989958/
https://www.ncbi.nlm.nih.gov/pubmed/33776439
http://dx.doi.org/10.2147/NDT.S299462
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