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Longitudinal Functional Study of Murine Aging: A Resource for Future Study Designs
Aging is characterized by systemic declines in tissue and organ functions. Interventions that slow these declines represent promising therapeutics to protect against age‐related disease and improve the quality of life. In this study, several interventions associated with lifespan extension in invert...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990142/ https://www.ncbi.nlm.nih.gov/pubmed/33778327 http://dx.doi.org/10.1002/jbm4.10466 |
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author | Evans, Daniel S O'Leary, Monique N Murphy, Ryan Schmidt, Minna Koenig, Kristin Presley, Michael Garrett, Brittany Kim, Ha‐Neui Han, Li Academia, Emmeline C Laye, Matt J Edgar, Daniel Zambataro, Christopher A Barhydt, Tracey Dewey, Colleen M Mayfield, Jarrott Wilson, Joy Alavez, Silvestre Lucanic, Mark Kennedy, Brian K Almeida, Maria Andersen, Julie K Kapahi, Pankaj Lithgow, Gordon J Melov, Simon |
author_facet | Evans, Daniel S O'Leary, Monique N Murphy, Ryan Schmidt, Minna Koenig, Kristin Presley, Michael Garrett, Brittany Kim, Ha‐Neui Han, Li Academia, Emmeline C Laye, Matt J Edgar, Daniel Zambataro, Christopher A Barhydt, Tracey Dewey, Colleen M Mayfield, Jarrott Wilson, Joy Alavez, Silvestre Lucanic, Mark Kennedy, Brian K Almeida, Maria Andersen, Julie K Kapahi, Pankaj Lithgow, Gordon J Melov, Simon |
author_sort | Evans, Daniel S |
collection | PubMed |
description | Aging is characterized by systemic declines in tissue and organ functions. Interventions that slow these declines represent promising therapeutics to protect against age‐related disease and improve the quality of life. In this study, several interventions associated with lifespan extension in invertebrates or improvement of age‐related disease were tested in mouse models to determine if they were effective in slowing tissue aging in a broad spectrum of functional assays. Benzoxazole, which extends the lifespan of Caenorhabditis elegans, slowed age‐related femoral bone loss in mice. Rates of change were established for clinically significant parameters in untreated mice, including kyphosis, blood glucose, body composition, activity, metabolic measures, and detailed parameters of skeletal aging in bone. These findings have implications for the study of preclinical physiological aging and therapies targeting aging. Finally, an online application was created that includes the calculated rates of change and that enables power and variance to be calculated for many clinically important metrics of aging with an emphasis on bone. This resource will help in future study designs employing novel interventions in aging mice. © 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC. on behalf of American Society for Bone and Mineral Research. |
format | Online Article Text |
id | pubmed-7990142 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79901422021-03-25 Longitudinal Functional Study of Murine Aging: A Resource for Future Study Designs Evans, Daniel S O'Leary, Monique N Murphy, Ryan Schmidt, Minna Koenig, Kristin Presley, Michael Garrett, Brittany Kim, Ha‐Neui Han, Li Academia, Emmeline C Laye, Matt J Edgar, Daniel Zambataro, Christopher A Barhydt, Tracey Dewey, Colleen M Mayfield, Jarrott Wilson, Joy Alavez, Silvestre Lucanic, Mark Kennedy, Brian K Almeida, Maria Andersen, Julie K Kapahi, Pankaj Lithgow, Gordon J Melov, Simon JBMR Plus Original Articles Aging is characterized by systemic declines in tissue and organ functions. Interventions that slow these declines represent promising therapeutics to protect against age‐related disease and improve the quality of life. In this study, several interventions associated with lifespan extension in invertebrates or improvement of age‐related disease were tested in mouse models to determine if they were effective in slowing tissue aging in a broad spectrum of functional assays. Benzoxazole, which extends the lifespan of Caenorhabditis elegans, slowed age‐related femoral bone loss in mice. Rates of change were established for clinically significant parameters in untreated mice, including kyphosis, blood glucose, body composition, activity, metabolic measures, and detailed parameters of skeletal aging in bone. These findings have implications for the study of preclinical physiological aging and therapies targeting aging. Finally, an online application was created that includes the calculated rates of change and that enables power and variance to be calculated for many clinically important metrics of aging with an emphasis on bone. This resource will help in future study designs employing novel interventions in aging mice. © 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC. on behalf of American Society for Bone and Mineral Research. John Wiley & Sons, Inc. 2021-02-16 /pmc/articles/PMC7990142/ /pubmed/33778327 http://dx.doi.org/10.1002/jbm4.10466 Text en © 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC. on behalf of American Society for Bone and Mineral Research. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Evans, Daniel S O'Leary, Monique N Murphy, Ryan Schmidt, Minna Koenig, Kristin Presley, Michael Garrett, Brittany Kim, Ha‐Neui Han, Li Academia, Emmeline C Laye, Matt J Edgar, Daniel Zambataro, Christopher A Barhydt, Tracey Dewey, Colleen M Mayfield, Jarrott Wilson, Joy Alavez, Silvestre Lucanic, Mark Kennedy, Brian K Almeida, Maria Andersen, Julie K Kapahi, Pankaj Lithgow, Gordon J Melov, Simon Longitudinal Functional Study of Murine Aging: A Resource for Future Study Designs |
title | Longitudinal Functional Study of Murine Aging: A Resource for Future Study Designs |
title_full | Longitudinal Functional Study of Murine Aging: A Resource for Future Study Designs |
title_fullStr | Longitudinal Functional Study of Murine Aging: A Resource for Future Study Designs |
title_full_unstemmed | Longitudinal Functional Study of Murine Aging: A Resource for Future Study Designs |
title_short | Longitudinal Functional Study of Murine Aging: A Resource for Future Study Designs |
title_sort | longitudinal functional study of murine aging: a resource for future study designs |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990142/ https://www.ncbi.nlm.nih.gov/pubmed/33778327 http://dx.doi.org/10.1002/jbm4.10466 |
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