T-cell receptor mimic (TCRm) antibody therapeutics against intracellular proteins

T-cell receptor mimic (TCRm) antibodies combine the capacity of a T cell to target intracellular antigens with other capacities unique to antibodies. Neoantigens are abnormal proteins that arise as a consequence of somatic mutations. Technological advances promote the development of neoantigen-targe...

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Detalles Bibliográficos
Autores principales: Xu, Yixiang, Salazar, Georgina To’a, Zhang, Ningyan, An, Zhiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990144/
https://www.ncbi.nlm.nih.gov/pubmed/33928218
http://dx.doi.org/10.1093/abt/tbz001
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author Xu, Yixiang
Salazar, Georgina To’a
Zhang, Ningyan
An, Zhiqiang
author_facet Xu, Yixiang
Salazar, Georgina To’a
Zhang, Ningyan
An, Zhiqiang
author_sort Xu, Yixiang
collection PubMed
description T-cell receptor mimic (TCRm) antibodies combine the capacity of a T cell to target intracellular antigens with other capacities unique to antibodies. Neoantigens are abnormal proteins that arise as a consequence of somatic mutations. Technological advances promote the development of neoantigen-targeting therapies including TCRm antibody therapies. This review summarizes key characteristics of TCRm antibodies, in particular those targeting neoantigens, and further introduces discussion of obstacles that must be overcome to advance TCRm therapeutics.
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spelling pubmed-79901442021-04-28 T-cell receptor mimic (TCRm) antibody therapeutics against intracellular proteins Xu, Yixiang Salazar, Georgina To’a Zhang, Ningyan An, Zhiqiang Antib Ther Review Article T-cell receptor mimic (TCRm) antibodies combine the capacity of a T cell to target intracellular antigens with other capacities unique to antibodies. Neoantigens are abnormal proteins that arise as a consequence of somatic mutations. Technological advances promote the development of neoantigen-targeting therapies including TCRm antibody therapies. This review summarizes key characteristics of TCRm antibodies, in particular those targeting neoantigens, and further introduces discussion of obstacles that must be overcome to advance TCRm therapeutics. Oxford University Press 2019-01-21 /pmc/articles/PMC7990144/ /pubmed/33928218 http://dx.doi.org/10.1093/abt/tbz001 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of Antibody Therapeutics. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Review Article
Xu, Yixiang
Salazar, Georgina To’a
Zhang, Ningyan
An, Zhiqiang
T-cell receptor mimic (TCRm) antibody therapeutics against intracellular proteins
title T-cell receptor mimic (TCRm) antibody therapeutics against intracellular proteins
title_full T-cell receptor mimic (TCRm) antibody therapeutics against intracellular proteins
title_fullStr T-cell receptor mimic (TCRm) antibody therapeutics against intracellular proteins
title_full_unstemmed T-cell receptor mimic (TCRm) antibody therapeutics against intracellular proteins
title_short T-cell receptor mimic (TCRm) antibody therapeutics against intracellular proteins
title_sort t-cell receptor mimic (tcrm) antibody therapeutics against intracellular proteins
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990144/
https://www.ncbi.nlm.nih.gov/pubmed/33928218
http://dx.doi.org/10.1093/abt/tbz001
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AT zhangningyan tcellreceptormimictcrmantibodytherapeuticsagainstintracellularproteins
AT anzhiqiang tcellreceptormimictcrmantibodytherapeuticsagainstintracellularproteins

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