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Effect of allotypic variation of human IgG1 on the thermal stability of disulfide-linked knobs-into-holes mutants of the Fc for stable bispecific antibody design

BACKGROUND: Disulfide-linked knobs-into-holes (dKiH) mutation is a well-validated antibody engineering technique to force heterodimer formation of different Fcs for efficient production of bispecific antibodies. An artificial disulfide bond is created between mutated cysteine residues in CH3 domain...

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Detalles Bibliográficos
Autores principales:	Akiba, Hiroki, Satoh, Reiko, Nagata, Satoshi, Tsumoto, Kouhei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Research article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990158/ https://www.ncbi.nlm.nih.gov/pubmed/33928224 http://dx.doi.org/10.1093/abt/tbz008

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