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Baseline clinical characteristics and prognostic factors in hospitalized COVID-19 patients aged ≤ 65 years: A retrospective observational study

BACKGROUND: Individual differences in susceptibility to SARS-CoV-2 infection, symptomatology and clinical manifestation of COVID-19 have thus far been observed but little is known about the prognostic factors of young patients. METHODS: A retrospective observational study was conducted on 171 patien...

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Autores principales: Betti, Marta, Bertolotti, Marinella, Ferrante, Daniela, Roveta, Annalisa, Pelazza, Carolina, Giacchero, Fabio, Penpa, Serena, Massarino, Costanza, Bolgeo, Tatiana, Cassinari, Antonella, Mussa, Marco, Chichino, Guido, Maconi, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990225/
https://www.ncbi.nlm.nih.gov/pubmed/33760885
http://dx.doi.org/10.1371/journal.pone.0248829
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author Betti, Marta
Bertolotti, Marinella
Ferrante, Daniela
Roveta, Annalisa
Pelazza, Carolina
Giacchero, Fabio
Penpa, Serena
Massarino, Costanza
Bolgeo, Tatiana
Cassinari, Antonella
Mussa, Marco
Chichino, Guido
Maconi, Antonio
author_facet Betti, Marta
Bertolotti, Marinella
Ferrante, Daniela
Roveta, Annalisa
Pelazza, Carolina
Giacchero, Fabio
Penpa, Serena
Massarino, Costanza
Bolgeo, Tatiana
Cassinari, Antonella
Mussa, Marco
Chichino, Guido
Maconi, Antonio
author_sort Betti, Marta
collection PubMed
description BACKGROUND: Individual differences in susceptibility to SARS-CoV-2 infection, symptomatology and clinical manifestation of COVID-19 have thus far been observed but little is known about the prognostic factors of young patients. METHODS: A retrospective observational study was conducted on 171 patients aged ≤ 65 years hospitalized in Alessandria’s Hospital from 1(st) March to 30(th) April 2020 with laboratory confirmed COVID-19. Epidemiological data, symptoms at onset, clinical manifestations, Charlson Comorbidity Index, laboratory parameters, radiological findings and complications were considered. Patients were divided into two groups on the basis of COVID-19 severity. Multivariable logistic regression analysis was used to establish factors associated with the development of a moderate or severe disease. FINDINGS: A total of 171 patients (89 with mild/moderate disease, 82 with severe/critical disease), of which 61% males and a mean age (± SD) of 53.6 (± 9.7) were included. The multivariable logistic model identified age (50–65 vs 18–49; OR = 3.23 CI95% 1.42–7.37), platelet count (per 100 units of increase OR = 0.61 CI95% 0.42–0.89), c-reactive protein (CPR) (per unit of increase OR = 1.12 CI95% 1.06–1.20) as risk factors for severe or critical disease. The multivariable logistic model showed a good discriminating capacity with a C-index value of 0.76. INTERPRETATION: Patients aged ≥ 50 years with low platelet count and high CRP are more likely to develop severe or critical illness. These findings might contribute to improved clinical management.
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spelling pubmed-79902252021-04-05 Baseline clinical characteristics and prognostic factors in hospitalized COVID-19 patients aged ≤ 65 years: A retrospective observational study Betti, Marta Bertolotti, Marinella Ferrante, Daniela Roveta, Annalisa Pelazza, Carolina Giacchero, Fabio Penpa, Serena Massarino, Costanza Bolgeo, Tatiana Cassinari, Antonella Mussa, Marco Chichino, Guido Maconi, Antonio PLoS One Research Article BACKGROUND: Individual differences in susceptibility to SARS-CoV-2 infection, symptomatology and clinical manifestation of COVID-19 have thus far been observed but little is known about the prognostic factors of young patients. METHODS: A retrospective observational study was conducted on 171 patients aged ≤ 65 years hospitalized in Alessandria’s Hospital from 1(st) March to 30(th) April 2020 with laboratory confirmed COVID-19. Epidemiological data, symptoms at onset, clinical manifestations, Charlson Comorbidity Index, laboratory parameters, radiological findings and complications were considered. Patients were divided into two groups on the basis of COVID-19 severity. Multivariable logistic regression analysis was used to establish factors associated with the development of a moderate or severe disease. FINDINGS: A total of 171 patients (89 with mild/moderate disease, 82 with severe/critical disease), of which 61% males and a mean age (± SD) of 53.6 (± 9.7) were included. The multivariable logistic model identified age (50–65 vs 18–49; OR = 3.23 CI95% 1.42–7.37), platelet count (per 100 units of increase OR = 0.61 CI95% 0.42–0.89), c-reactive protein (CPR) (per unit of increase OR = 1.12 CI95% 1.06–1.20) as risk factors for severe or critical disease. The multivariable logistic model showed a good discriminating capacity with a C-index value of 0.76. INTERPRETATION: Patients aged ≥ 50 years with low platelet count and high CRP are more likely to develop severe or critical illness. These findings might contribute to improved clinical management. Public Library of Science 2021-03-24 /pmc/articles/PMC7990225/ /pubmed/33760885 http://dx.doi.org/10.1371/journal.pone.0248829 Text en © 2021 Betti et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Betti, Marta
Bertolotti, Marinella
Ferrante, Daniela
Roveta, Annalisa
Pelazza, Carolina
Giacchero, Fabio
Penpa, Serena
Massarino, Costanza
Bolgeo, Tatiana
Cassinari, Antonella
Mussa, Marco
Chichino, Guido
Maconi, Antonio
Baseline clinical characteristics and prognostic factors in hospitalized COVID-19 patients aged ≤ 65 years: A retrospective observational study
title Baseline clinical characteristics and prognostic factors in hospitalized COVID-19 patients aged ≤ 65 years: A retrospective observational study
title_full Baseline clinical characteristics and prognostic factors in hospitalized COVID-19 patients aged ≤ 65 years: A retrospective observational study
title_fullStr Baseline clinical characteristics and prognostic factors in hospitalized COVID-19 patients aged ≤ 65 years: A retrospective observational study
title_full_unstemmed Baseline clinical characteristics and prognostic factors in hospitalized COVID-19 patients aged ≤ 65 years: A retrospective observational study
title_short Baseline clinical characteristics and prognostic factors in hospitalized COVID-19 patients aged ≤ 65 years: A retrospective observational study
title_sort baseline clinical characteristics and prognostic factors in hospitalized covid-19 patients aged ≤ 65 years: a retrospective observational study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990225/
https://www.ncbi.nlm.nih.gov/pubmed/33760885
http://dx.doi.org/10.1371/journal.pone.0248829
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