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Activity data from wearables as an indicator of functional capacity in patients with cardiovascular disease

BACKGROUND: Smartphone and wearable-based activity data provide an opportunity to remotely monitor functional capacity in patients. In this study, we assessed the ability of a home-based 6-minute walk test (6MWT) as well as passively collected activity data to supplement or even replace the in-clini...

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Autores principales: Rens, Neil, Gandhi, Neil, Mak, Jonathan, Paul, Jeddeo, Bent, Drew, Liu, Stephanie, Savage, Dasha, Nielsen-Bowles, Helle, Triggs, Doran, Ata, Ghausia, Talgo, Julia, Gutierrez, Santiago, Aalami, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990307/
https://www.ncbi.nlm.nih.gov/pubmed/33760846
http://dx.doi.org/10.1371/journal.pone.0247834
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author Rens, Neil
Gandhi, Neil
Mak, Jonathan
Paul, Jeddeo
Bent, Drew
Liu, Stephanie
Savage, Dasha
Nielsen-Bowles, Helle
Triggs, Doran
Ata, Ghausia
Talgo, Julia
Gutierrez, Santiago
Aalami, Oliver
author_facet Rens, Neil
Gandhi, Neil
Mak, Jonathan
Paul, Jeddeo
Bent, Drew
Liu, Stephanie
Savage, Dasha
Nielsen-Bowles, Helle
Triggs, Doran
Ata, Ghausia
Talgo, Julia
Gutierrez, Santiago
Aalami, Oliver
author_sort Rens, Neil
collection PubMed
description BACKGROUND: Smartphone and wearable-based activity data provide an opportunity to remotely monitor functional capacity in patients. In this study, we assessed the ability of a home-based 6-minute walk test (6MWT) as well as passively collected activity data to supplement or even replace the in-clinic 6MWTs in patients with cardiovascular disease. METHODS: We enrolled 110 participants who were scheduled for vascular or cardiac procedures. Each participant was supplied with an iPhone and an Apple Watch running the VascTrac research app and was followed for 6 months. Supervised 6MWTs were performed during clinic visits at scheduled intervals. Weekly at-home 6MWTs were performed via the VascTrac app. The app passively collected activity data such as daily step counts. Logistic regression with forward feature selection was used to assess at-home 6MWT and passive data as predictors for “frailty” as measured by the gold-standard supervised 6MWT. Frailty was defined as walking <300m on an in-clinic 6MWT. RESULTS: Under a supervised in-clinic setting, the smartphone and Apple Watch with the VascTrac app were able to accurately assess ‘frailty’ with sensitivity of 90% and specificity of 85%. Outside the clinic in an unsupervised setting, the home-based 6MWT is 83% sensitive and 60% specific in assessing “frailty.” Passive data collected at home were nearly as accurate at predicting frailty on a clinic-based 6MWT as was a home-based 6MWT, with area under curve (AUC) of 0.643 and 0.704, respectively. CONCLUSIONS: In this longitudinal observational study, passive activity data acquired by an iPhone and Apple Watch were an accurate predictor of in-clinic 6MWT performance. This finding suggests that frailty and functional capacity could be monitored and evaluated remotely in patients with cardiovascular disease, enabling safer and higher resolution monitoring of patients.
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spelling pubmed-79903072021-04-05 Activity data from wearables as an indicator of functional capacity in patients with cardiovascular disease Rens, Neil Gandhi, Neil Mak, Jonathan Paul, Jeddeo Bent, Drew Liu, Stephanie Savage, Dasha Nielsen-Bowles, Helle Triggs, Doran Ata, Ghausia Talgo, Julia Gutierrez, Santiago Aalami, Oliver PLoS One Research Article BACKGROUND: Smartphone and wearable-based activity data provide an opportunity to remotely monitor functional capacity in patients. In this study, we assessed the ability of a home-based 6-minute walk test (6MWT) as well as passively collected activity data to supplement or even replace the in-clinic 6MWTs in patients with cardiovascular disease. METHODS: We enrolled 110 participants who were scheduled for vascular or cardiac procedures. Each participant was supplied with an iPhone and an Apple Watch running the VascTrac research app and was followed for 6 months. Supervised 6MWTs were performed during clinic visits at scheduled intervals. Weekly at-home 6MWTs were performed via the VascTrac app. The app passively collected activity data such as daily step counts. Logistic regression with forward feature selection was used to assess at-home 6MWT and passive data as predictors for “frailty” as measured by the gold-standard supervised 6MWT. Frailty was defined as walking <300m on an in-clinic 6MWT. RESULTS: Under a supervised in-clinic setting, the smartphone and Apple Watch with the VascTrac app were able to accurately assess ‘frailty’ with sensitivity of 90% and specificity of 85%. Outside the clinic in an unsupervised setting, the home-based 6MWT is 83% sensitive and 60% specific in assessing “frailty.” Passive data collected at home were nearly as accurate at predicting frailty on a clinic-based 6MWT as was a home-based 6MWT, with area under curve (AUC) of 0.643 and 0.704, respectively. CONCLUSIONS: In this longitudinal observational study, passive activity data acquired by an iPhone and Apple Watch were an accurate predictor of in-clinic 6MWT performance. This finding suggests that frailty and functional capacity could be monitored and evaluated remotely in patients with cardiovascular disease, enabling safer and higher resolution monitoring of patients. Public Library of Science 2021-03-24 /pmc/articles/PMC7990307/ /pubmed/33760846 http://dx.doi.org/10.1371/journal.pone.0247834 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Research Article
Rens, Neil
Gandhi, Neil
Mak, Jonathan
Paul, Jeddeo
Bent, Drew
Liu, Stephanie
Savage, Dasha
Nielsen-Bowles, Helle
Triggs, Doran
Ata, Ghausia
Talgo, Julia
Gutierrez, Santiago
Aalami, Oliver
Activity data from wearables as an indicator of functional capacity in patients with cardiovascular disease
title Activity data from wearables as an indicator of functional capacity in patients with cardiovascular disease
title_full Activity data from wearables as an indicator of functional capacity in patients with cardiovascular disease
title_fullStr Activity data from wearables as an indicator of functional capacity in patients with cardiovascular disease
title_full_unstemmed Activity data from wearables as an indicator of functional capacity in patients with cardiovascular disease
title_short Activity data from wearables as an indicator of functional capacity in patients with cardiovascular disease
title_sort activity data from wearables as an indicator of functional capacity in patients with cardiovascular disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990307/
https://www.ncbi.nlm.nih.gov/pubmed/33760846
http://dx.doi.org/10.1371/journal.pone.0247834
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