Adipose tissue parasite sequestration drives leptin production in mice and correlates with human cerebral malaria

Circulating levels of the adipokine leptin are linked to neuropathology in experimental cerebral malaria (ECM), but its source and regulation mechanism remain unknown. Here, we show that sequestration of infected red blood cells (iRBCs) in white adipose tissue (WAT) microvasculature increased local...

Descripción completa

Detalles Bibliográficos
Autores principales: Mejia, Pedro, Treviño-Villarreal, J. Humberto, De Niz, Mariana, Meibalan, Elamaran, Longchamp, Alban, Reynolds, Justin S., Turnbull, Lindsey B., Opoka, Robert O., Roussilhon, Christian, Spielmann, Tobias, Ozaki, C. Keith, Heussler, Volker T., Seydel, Karl B., Taylor, Terrie E., John, Chandy C., Milner, Danny A., Marti, Matthias, Mitchell, James R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990332/
https://www.ncbi.nlm.nih.gov/pubmed/33762334
http://dx.doi.org/10.1126/sciadv.abe2484

Ejemplares similares

Ejemplares similares