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Aging and Renal Disease: Old Questions for New Challenges

Chronic kidney disease (CKD) is a growing problem among aging population, and the number of individuals at risk of end stage renal disease is rising. Part of the reason lies in incomplete understanding of the pathways underlying renal aging and kidney disease, as well as insufficient delivery of evi...

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Detalles Bibliográficos
Autores principales: Chou, Yu-Hsiang, Chen, Yung-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JKL International LLC 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990354/
https://www.ncbi.nlm.nih.gov/pubmed/33815880
http://dx.doi.org/10.14336/AD.2020.0703
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author Chou, Yu-Hsiang
Chen, Yung-Ming
author_facet Chou, Yu-Hsiang
Chen, Yung-Ming
author_sort Chou, Yu-Hsiang
collection PubMed
description Chronic kidney disease (CKD) is a growing problem among aging population, and the number of individuals at risk of end stage renal disease is rising. Part of the reason lies in incomplete understanding of the pathways underlying renal aging and kidney disease, as well as insufficient delivery of evidence-based treatment to elderly patients with CKD. This review aims to address these unsolved issues by delineating updated mechanisms of renal senescence and summarizing recent findings on key clinical aspects of CKD in the elderly. Challenges and obstacles in caring for older people with CKD are discussed, with an emphasis on modification of risk factors, prevention of acute kidney injury, stabilization of progression and decision on dialysis initiation.
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spelling pubmed-79903542021-04-03 Aging and Renal Disease: Old Questions for New Challenges Chou, Yu-Hsiang Chen, Yung-Ming Aging Dis Review Chronic kidney disease (CKD) is a growing problem among aging population, and the number of individuals at risk of end stage renal disease is rising. Part of the reason lies in incomplete understanding of the pathways underlying renal aging and kidney disease, as well as insufficient delivery of evidence-based treatment to elderly patients with CKD. This review aims to address these unsolved issues by delineating updated mechanisms of renal senescence and summarizing recent findings on key clinical aspects of CKD in the elderly. Challenges and obstacles in caring for older people with CKD are discussed, with an emphasis on modification of risk factors, prevention of acute kidney injury, stabilization of progression and decision on dialysis initiation. JKL International LLC 2021-04-01 /pmc/articles/PMC7990354/ /pubmed/33815880 http://dx.doi.org/10.14336/AD.2020.0703 Text en copyright: © 2021 Chou et al. http://creativecommons.org/licenses/by/2.0/ this is an open access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Review
Chou, Yu-Hsiang
Chen, Yung-Ming
Aging and Renal Disease: Old Questions for New Challenges
title Aging and Renal Disease: Old Questions for New Challenges
title_full Aging and Renal Disease: Old Questions for New Challenges
title_fullStr Aging and Renal Disease: Old Questions for New Challenges
title_full_unstemmed Aging and Renal Disease: Old Questions for New Challenges
title_short Aging and Renal Disease: Old Questions for New Challenges
title_sort aging and renal disease: old questions for new challenges
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990354/
https://www.ncbi.nlm.nih.gov/pubmed/33815880
http://dx.doi.org/10.14336/AD.2020.0703
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