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Microglial Polarization: Novel Therapeutic Strategy against Ischemic Stroke
Ischemic stroke, which is the second highest cause of death and the leading cause of disability, represents ~71% of all strokes globally. Some studies have found that the key elements of the pathobiology of stroke is immunity and inflammation. Microglia are the first line of defense in the nervous s...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
JKL International LLC
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990355/ https://www.ncbi.nlm.nih.gov/pubmed/33815877 http://dx.doi.org/10.14336/AD.2020.0701 |
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author | Xue, Yimeng Nie, Ding Wang, Lin-Jian Qiu, Han-Cheng Ma, Long Dong, Ming-Xin Tu, Wen-Jun Zhao, Jizong |
author_facet | Xue, Yimeng Nie, Ding Wang, Lin-Jian Qiu, Han-Cheng Ma, Long Dong, Ming-Xin Tu, Wen-Jun Zhao, Jizong |
author_sort | Xue, Yimeng |
collection | PubMed |
description | Ischemic stroke, which is the second highest cause of death and the leading cause of disability, represents ~71% of all strokes globally. Some studies have found that the key elements of the pathobiology of stroke is immunity and inflammation. Microglia are the first line of defense in the nervous system. After stroke, the activated microglia become a double-edged sword, with distinct phenotypic changes to the deleterious M1 types and neuroprotective M2 types. Therefore, ways to promote microglial polarization toward M2 phenotype after stroke have become the focus of attention in recent years. In this review, we discuss the process of microglial polarization, summarize the alternation of signaling pathways and epigenetic regulation that control microglial polarization in ischemic stroke, aiming to find the potential mechanisms by which microglia can be transformed into the M2 polarized phenotype. |
format | Online Article Text |
id | pubmed-7990355 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | JKL International LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-79903552021-04-03 Microglial Polarization: Novel Therapeutic Strategy against Ischemic Stroke Xue, Yimeng Nie, Ding Wang, Lin-Jian Qiu, Han-Cheng Ma, Long Dong, Ming-Xin Tu, Wen-Jun Zhao, Jizong Aging Dis Review Ischemic stroke, which is the second highest cause of death and the leading cause of disability, represents ~71% of all strokes globally. Some studies have found that the key elements of the pathobiology of stroke is immunity and inflammation. Microglia are the first line of defense in the nervous system. After stroke, the activated microglia become a double-edged sword, with distinct phenotypic changes to the deleterious M1 types and neuroprotective M2 types. Therefore, ways to promote microglial polarization toward M2 phenotype after stroke have become the focus of attention in recent years. In this review, we discuss the process of microglial polarization, summarize the alternation of signaling pathways and epigenetic regulation that control microglial polarization in ischemic stroke, aiming to find the potential mechanisms by which microglia can be transformed into the M2 polarized phenotype. JKL International LLC 2021-04-01 /pmc/articles/PMC7990355/ /pubmed/33815877 http://dx.doi.org/10.14336/AD.2020.0701 Text en copyright: © 2021 Xue et al. http://creativecommons.org/licenses/by/2.0/ this is an open access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Review Xue, Yimeng Nie, Ding Wang, Lin-Jian Qiu, Han-Cheng Ma, Long Dong, Ming-Xin Tu, Wen-Jun Zhao, Jizong Microglial Polarization: Novel Therapeutic Strategy against Ischemic Stroke |
title | Microglial Polarization: Novel Therapeutic Strategy against Ischemic Stroke |
title_full | Microglial Polarization: Novel Therapeutic Strategy against Ischemic Stroke |
title_fullStr | Microglial Polarization: Novel Therapeutic Strategy against Ischemic Stroke |
title_full_unstemmed | Microglial Polarization: Novel Therapeutic Strategy against Ischemic Stroke |
title_short | Microglial Polarization: Novel Therapeutic Strategy against Ischemic Stroke |
title_sort | microglial polarization: novel therapeutic strategy against ischemic stroke |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990355/ https://www.ncbi.nlm.nih.gov/pubmed/33815877 http://dx.doi.org/10.14336/AD.2020.0701 |
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