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Terminal Schwann Cell Aging: Implications for Age-Associated Neuromuscular Dysfunction

Action potential is transmitted to muscle fibers through specialized synaptic interfaces called neuromuscular junctions (NMJs). These structures are capped by terminal Schwann cells (tSCs), which play essential roles during formation and maintenance of the NMJ. tSCs are implicated in the correct com...

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Detalles Bibliográficos
Autores principales: Fuertes-Alvarez, Sandra, Izeta, Ander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JKL International LLC 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990373/
https://www.ncbi.nlm.nih.gov/pubmed/33815879
http://dx.doi.org/10.14336/AD.2020.0708
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author Fuertes-Alvarez, Sandra
Izeta, Ander
author_facet Fuertes-Alvarez, Sandra
Izeta, Ander
author_sort Fuertes-Alvarez, Sandra
collection PubMed
description Action potential is transmitted to muscle fibers through specialized synaptic interfaces called neuromuscular junctions (NMJs). These structures are capped by terminal Schwann cells (tSCs), which play essential roles during formation and maintenance of the NMJ. tSCs are implicated in the correct communication between nerves and muscles, and in reinnervation upon injury. During aging, loss of muscle mass and strength (sarcopenia and dynapenia) are due, at least in part, to the progressive loss of contacts between muscle fibers and nerves. Despite the important role of tSCs in NMJ function, very little is known on their implication in the NMJ-aging process and in age-associated denervation. This review summarizes the current knowledge about the implication of tSCs in the age-associated degeneration of NMJs. We also speculate on the possible mechanisms underlying the observed phenotypes.
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spelling pubmed-79903732021-04-03 Terminal Schwann Cell Aging: Implications for Age-Associated Neuromuscular Dysfunction Fuertes-Alvarez, Sandra Izeta, Ander Aging Dis Review Action potential is transmitted to muscle fibers through specialized synaptic interfaces called neuromuscular junctions (NMJs). These structures are capped by terminal Schwann cells (tSCs), which play essential roles during formation and maintenance of the NMJ. tSCs are implicated in the correct communication between nerves and muscles, and in reinnervation upon injury. During aging, loss of muscle mass and strength (sarcopenia and dynapenia) are due, at least in part, to the progressive loss of contacts between muscle fibers and nerves. Despite the important role of tSCs in NMJ function, very little is known on their implication in the NMJ-aging process and in age-associated denervation. This review summarizes the current knowledge about the implication of tSCs in the age-associated degeneration of NMJs. We also speculate on the possible mechanisms underlying the observed phenotypes. JKL International LLC 2021-04-01 /pmc/articles/PMC7990373/ /pubmed/33815879 http://dx.doi.org/10.14336/AD.2020.0708 Text en copyright: © 2021 Fuertes-Alvarez et al. http://creativecommons.org/licenses/by/2.0/ this is an open access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Review
Fuertes-Alvarez, Sandra
Izeta, Ander
Terminal Schwann Cell Aging: Implications for Age-Associated Neuromuscular Dysfunction
title Terminal Schwann Cell Aging: Implications for Age-Associated Neuromuscular Dysfunction
title_full Terminal Schwann Cell Aging: Implications for Age-Associated Neuromuscular Dysfunction
title_fullStr Terminal Schwann Cell Aging: Implications for Age-Associated Neuromuscular Dysfunction
title_full_unstemmed Terminal Schwann Cell Aging: Implications for Age-Associated Neuromuscular Dysfunction
title_short Terminal Schwann Cell Aging: Implications for Age-Associated Neuromuscular Dysfunction
title_sort terminal schwann cell aging: implications for age-associated neuromuscular dysfunction
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990373/
https://www.ncbi.nlm.nih.gov/pubmed/33815879
http://dx.doi.org/10.14336/AD.2020.0708
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