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Terminal Schwann Cell Aging: Implications for Age-Associated Neuromuscular Dysfunction
Action potential is transmitted to muscle fibers through specialized synaptic interfaces called neuromuscular junctions (NMJs). These structures are capped by terminal Schwann cells (tSCs), which play essential roles during formation and maintenance of the NMJ. tSCs are implicated in the correct com...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
JKL International LLC
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990373/ https://www.ncbi.nlm.nih.gov/pubmed/33815879 http://dx.doi.org/10.14336/AD.2020.0708 |
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author | Fuertes-Alvarez, Sandra Izeta, Ander |
author_facet | Fuertes-Alvarez, Sandra Izeta, Ander |
author_sort | Fuertes-Alvarez, Sandra |
collection | PubMed |
description | Action potential is transmitted to muscle fibers through specialized synaptic interfaces called neuromuscular junctions (NMJs). These structures are capped by terminal Schwann cells (tSCs), which play essential roles during formation and maintenance of the NMJ. tSCs are implicated in the correct communication between nerves and muscles, and in reinnervation upon injury. During aging, loss of muscle mass and strength (sarcopenia and dynapenia) are due, at least in part, to the progressive loss of contacts between muscle fibers and nerves. Despite the important role of tSCs in NMJ function, very little is known on their implication in the NMJ-aging process and in age-associated denervation. This review summarizes the current knowledge about the implication of tSCs in the age-associated degeneration of NMJs. We also speculate on the possible mechanisms underlying the observed phenotypes. |
format | Online Article Text |
id | pubmed-7990373 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | JKL International LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-79903732021-04-03 Terminal Schwann Cell Aging: Implications for Age-Associated Neuromuscular Dysfunction Fuertes-Alvarez, Sandra Izeta, Ander Aging Dis Review Action potential is transmitted to muscle fibers through specialized synaptic interfaces called neuromuscular junctions (NMJs). These structures are capped by terminal Schwann cells (tSCs), which play essential roles during formation and maintenance of the NMJ. tSCs are implicated in the correct communication between nerves and muscles, and in reinnervation upon injury. During aging, loss of muscle mass and strength (sarcopenia and dynapenia) are due, at least in part, to the progressive loss of contacts between muscle fibers and nerves. Despite the important role of tSCs in NMJ function, very little is known on their implication in the NMJ-aging process and in age-associated denervation. This review summarizes the current knowledge about the implication of tSCs in the age-associated degeneration of NMJs. We also speculate on the possible mechanisms underlying the observed phenotypes. JKL International LLC 2021-04-01 /pmc/articles/PMC7990373/ /pubmed/33815879 http://dx.doi.org/10.14336/AD.2020.0708 Text en copyright: © 2021 Fuertes-Alvarez et al. http://creativecommons.org/licenses/by/2.0/ this is an open access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Review Fuertes-Alvarez, Sandra Izeta, Ander Terminal Schwann Cell Aging: Implications for Age-Associated Neuromuscular Dysfunction |
title | Terminal Schwann Cell Aging: Implications for Age-Associated Neuromuscular Dysfunction |
title_full | Terminal Schwann Cell Aging: Implications for Age-Associated Neuromuscular Dysfunction |
title_fullStr | Terminal Schwann Cell Aging: Implications for Age-Associated Neuromuscular Dysfunction |
title_full_unstemmed | Terminal Schwann Cell Aging: Implications for Age-Associated Neuromuscular Dysfunction |
title_short | Terminal Schwann Cell Aging: Implications for Age-Associated Neuromuscular Dysfunction |
title_sort | terminal schwann cell aging: implications for age-associated neuromuscular dysfunction |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990373/ https://www.ncbi.nlm.nih.gov/pubmed/33815879 http://dx.doi.org/10.14336/AD.2020.0708 |
work_keys_str_mv | AT fuertesalvarezsandra terminalschwanncellagingimplicationsforageassociatedneuromusculardysfunction AT izetaander terminalschwanncellagingimplicationsforageassociatedneuromusculardysfunction |