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Neurobiological Pathways Linking Acute Mental Stress to Impairments in Executive Function in Individuals with Coronary Artery Disease

BACKGROUND: Individuals with coronary artery disease (CAD) have worse executive function compared to the general population but the mechanisms are unknown. OBJECTIVE: To investigate the role of acute mental stress (MS) on the executive function of patients with CAD. METHODS: Participants with stable...

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Autores principales: Moazzami, Kasra, Wittbrodt, Matthew T., Lima, Bruno B., Kim, Jeong Hwan, Almuwaqqat, Zakaria, Shah, Amit J., Hajjar, Ihab, Goldstein, Felicia C., Levey, Allan I., Nye, Jonathon A., Bremner, J. Douglas, Vaccarino, Viola, Quyyumi, Arshed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990469/
https://www.ncbi.nlm.nih.gov/pubmed/33782663
http://dx.doi.org/10.3233/ADR-200287
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author Moazzami, Kasra
Wittbrodt, Matthew T.
Lima, Bruno B.
Kim, Jeong Hwan
Almuwaqqat, Zakaria
Shah, Amit J.
Hajjar, Ihab
Goldstein, Felicia C.
Levey, Allan I.
Nye, Jonathon A.
Bremner, J. Douglas
Vaccarino, Viola
Quyyumi, Arshed A.
author_facet Moazzami, Kasra
Wittbrodt, Matthew T.
Lima, Bruno B.
Kim, Jeong Hwan
Almuwaqqat, Zakaria
Shah, Amit J.
Hajjar, Ihab
Goldstein, Felicia C.
Levey, Allan I.
Nye, Jonathon A.
Bremner, J. Douglas
Vaccarino, Viola
Quyyumi, Arshed A.
author_sort Moazzami, Kasra
collection PubMed
description BACKGROUND: Individuals with coronary artery disease (CAD) have worse executive function compared to the general population but the mechanisms are unknown. OBJECTIVE: To investigate the role of acute mental stress (MS) on the executive function of patients with CAD. METHODS: Participants with stable CAD underwent acute MS testing with simultaneous peripheral vascular function measurements and brain imaging using high resolution-positron emission tomography. Digital pulse wave amplitude was continuously measured using peripheral artery tonometry (PAT, Itamar Inc). Stress/rest PAT ratio (sPAT) of pulse wave amplitude during MS/baseline was calculated as a measure of microvascular constriction during MS. Plasma levels of catecholamine and interleukin-6 were assessed at baseline and after MS. Executive function was assessed both at baseline and at 2 years follow-up using the Trail Making Test parts A and B. RESULTS: We studied 389 individuals with brain data available for 148 participants. Of this population follow-up cognitive assessments were performed in 226 individuals (121 with brain imaging). After multivariable adjustment for baseline demographics, risk factors, and medication use, a lower sPAT, indicating greater vasoconstriction, a higher inferior frontal lobe activation with MS, and increases in norepinephrine and IL-6 levels with MS were all independently associated with greater time to complete Trail B test.-38.4pt CONCLUSION: In response to acute MS, greater peripheral vasoconstriction, higher inferior frontal lobe brain activation, and increases in the levels of norepinephrine and IL-6 are associated with worse executive function.
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spelling pubmed-79904692021-03-28 Neurobiological Pathways Linking Acute Mental Stress to Impairments in Executive Function in Individuals with Coronary Artery Disease Moazzami, Kasra Wittbrodt, Matthew T. Lima, Bruno B. Kim, Jeong Hwan Almuwaqqat, Zakaria Shah, Amit J. Hajjar, Ihab Goldstein, Felicia C. Levey, Allan I. Nye, Jonathon A. Bremner, J. Douglas Vaccarino, Viola Quyyumi, Arshed A. J Alzheimers Dis Rep Research Report BACKGROUND: Individuals with coronary artery disease (CAD) have worse executive function compared to the general population but the mechanisms are unknown. OBJECTIVE: To investigate the role of acute mental stress (MS) on the executive function of patients with CAD. METHODS: Participants with stable CAD underwent acute MS testing with simultaneous peripheral vascular function measurements and brain imaging using high resolution-positron emission tomography. Digital pulse wave amplitude was continuously measured using peripheral artery tonometry (PAT, Itamar Inc). Stress/rest PAT ratio (sPAT) of pulse wave amplitude during MS/baseline was calculated as a measure of microvascular constriction during MS. Plasma levels of catecholamine and interleukin-6 were assessed at baseline and after MS. Executive function was assessed both at baseline and at 2 years follow-up using the Trail Making Test parts A and B. RESULTS: We studied 389 individuals with brain data available for 148 participants. Of this population follow-up cognitive assessments were performed in 226 individuals (121 with brain imaging). After multivariable adjustment for baseline demographics, risk factors, and medication use, a lower sPAT, indicating greater vasoconstriction, a higher inferior frontal lobe activation with MS, and increases in norepinephrine and IL-6 levels with MS were all independently associated with greater time to complete Trail B test.-38.4pt CONCLUSION: In response to acute MS, greater peripheral vasoconstriction, higher inferior frontal lobe brain activation, and increases in the levels of norepinephrine and IL-6 are associated with worse executive function. IOS Press 2021-02-02 /pmc/articles/PMC7990469/ /pubmed/33782663 http://dx.doi.org/10.3233/ADR-200287 Text en © 2021 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Report
Moazzami, Kasra
Wittbrodt, Matthew T.
Lima, Bruno B.
Kim, Jeong Hwan
Almuwaqqat, Zakaria
Shah, Amit J.
Hajjar, Ihab
Goldstein, Felicia C.
Levey, Allan I.
Nye, Jonathon A.
Bremner, J. Douglas
Vaccarino, Viola
Quyyumi, Arshed A.
Neurobiological Pathways Linking Acute Mental Stress to Impairments in Executive Function in Individuals with Coronary Artery Disease
title Neurobiological Pathways Linking Acute Mental Stress to Impairments in Executive Function in Individuals with Coronary Artery Disease
title_full Neurobiological Pathways Linking Acute Mental Stress to Impairments in Executive Function in Individuals with Coronary Artery Disease
title_fullStr Neurobiological Pathways Linking Acute Mental Stress to Impairments in Executive Function in Individuals with Coronary Artery Disease
title_full_unstemmed Neurobiological Pathways Linking Acute Mental Stress to Impairments in Executive Function in Individuals with Coronary Artery Disease
title_short Neurobiological Pathways Linking Acute Mental Stress to Impairments in Executive Function in Individuals with Coronary Artery Disease
title_sort neurobiological pathways linking acute mental stress to impairments in executive function in individuals with coronary artery disease
topic Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990469/
https://www.ncbi.nlm.nih.gov/pubmed/33782663
http://dx.doi.org/10.3233/ADR-200287
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