Propionibacterium acnes-associated Sarcoidosis Possibly Initially Triggered by Interferon-alpha Therapy

A 46-year-old woman with uveitis was referred to our respiratory diseases department in July 2018. Her medical history included transient bilateral hilar mediastinal lymphadenopathy (BHL) and multiple pulmonary nodules in May 2013 during pegylated interferon-alpha and ribavirin treatment for chronic...

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Autores principales: Sawahata, Michiru, Fujiki, Yasumaro, Nakano, Naomi, Ohtsuki, Mamitaro, Yamaguchi, Tetsuo, Uchida, Keisuke, Eishi, Yoshinobu, Suzuki, Takuji, Hagiwara, Koichi, Bando, Masashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990622/
https://www.ncbi.nlm.nih.gov/pubmed/32999227
http://dx.doi.org/10.2169/internalmedicine.5281-20
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author Sawahata, Michiru
Fujiki, Yasumaro
Nakano, Naomi
Ohtsuki, Mamitaro
Yamaguchi, Tetsuo
Uchida, Keisuke
Eishi, Yoshinobu
Suzuki, Takuji
Hagiwara, Koichi
Bando, Masashi
author_facet Sawahata, Michiru
Fujiki, Yasumaro
Nakano, Naomi
Ohtsuki, Mamitaro
Yamaguchi, Tetsuo
Uchida, Keisuke
Eishi, Yoshinobu
Suzuki, Takuji
Hagiwara, Koichi
Bando, Masashi
author_sort Sawahata, Michiru
collection PubMed
description A 46-year-old woman with uveitis was referred to our respiratory diseases department in July 2018. Her medical history included transient bilateral hilar mediastinal lymphadenopathy (BHL) and multiple pulmonary nodules in May 2013 during pegylated interferon-alpha and ribavirin treatment for chronic hepatitis C infection. Five years post-treatment, chest X-ray revealed BHL and nodular recurrence. A biopsy of the subcutaneous buttock nodules revealed scattered non-caseating epithelioid granulomas with positive PAB immunohistochemical staining. This seem to be the first report of Propionibacterium acnes-associated sarcoidosis possibly initially triggered by interferon-alpha therapy. Understanding the mechanisms underlying interferon-triggered P. acnes-associated sarcoidosis may clarify the sarcoidosis immunopathogenesis.
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spelling pubmed-79906222021-03-29 Propionibacterium acnes-associated Sarcoidosis Possibly Initially Triggered by Interferon-alpha Therapy Sawahata, Michiru Fujiki, Yasumaro Nakano, Naomi Ohtsuki, Mamitaro Yamaguchi, Tetsuo Uchida, Keisuke Eishi, Yoshinobu Suzuki, Takuji Hagiwara, Koichi Bando, Masashi Intern Med Case Report A 46-year-old woman with uveitis was referred to our respiratory diseases department in July 2018. Her medical history included transient bilateral hilar mediastinal lymphadenopathy (BHL) and multiple pulmonary nodules in May 2013 during pegylated interferon-alpha and ribavirin treatment for chronic hepatitis C infection. Five years post-treatment, chest X-ray revealed BHL and nodular recurrence. A biopsy of the subcutaneous buttock nodules revealed scattered non-caseating epithelioid granulomas with positive PAB immunohistochemical staining. This seem to be the first report of Propionibacterium acnes-associated sarcoidosis possibly initially triggered by interferon-alpha therapy. Understanding the mechanisms underlying interferon-triggered P. acnes-associated sarcoidosis may clarify the sarcoidosis immunopathogenesis. The Japanese Society of Internal Medicine 2020-09-30 2021-03-01 /pmc/articles/PMC7990622/ /pubmed/32999227 http://dx.doi.org/10.2169/internalmedicine.5281-20 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Sawahata, Michiru
Fujiki, Yasumaro
Nakano, Naomi
Ohtsuki, Mamitaro
Yamaguchi, Tetsuo
Uchida, Keisuke
Eishi, Yoshinobu
Suzuki, Takuji
Hagiwara, Koichi
Bando, Masashi
Propionibacterium acnes-associated Sarcoidosis Possibly Initially Triggered by Interferon-alpha Therapy
title Propionibacterium acnes-associated Sarcoidosis Possibly Initially Triggered by Interferon-alpha Therapy
title_full Propionibacterium acnes-associated Sarcoidosis Possibly Initially Triggered by Interferon-alpha Therapy
title_fullStr Propionibacterium acnes-associated Sarcoidosis Possibly Initially Triggered by Interferon-alpha Therapy
title_full_unstemmed Propionibacterium acnes-associated Sarcoidosis Possibly Initially Triggered by Interferon-alpha Therapy
title_short Propionibacterium acnes-associated Sarcoidosis Possibly Initially Triggered by Interferon-alpha Therapy
title_sort propionibacterium acnes-associated sarcoidosis possibly initially triggered by interferon-alpha therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990622/
https://www.ncbi.nlm.nih.gov/pubmed/32999227
http://dx.doi.org/10.2169/internalmedicine.5281-20
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