Anti-glomerular Basement Membrane Glomerulonephritis During the First Trimester of Pregnancy

A 28-year-old woman was admitted during the eighth week of her pregnancy because her clinical course was consistent with rapid progressive glomerulonephritis (RPGN). Anti-glomerular basement membrane antibody (anti-GBM Ab) and myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) were posi...

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Detalles Bibliográficos
Autores principales: Kai, Hirayasu, Usui, Joichi, Tawara, Takashi, Takahashi-Kobayashi, Mayumi, Ishii, Ryota, Tsunoda, Ryoya, Fujita, Akiko, Nagai, Kei, Kaneko, Shuzo, Morito, Naoki, Saito, Chie, Hamada, Hiromi, Yamagata, Kunihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990629/
https://www.ncbi.nlm.nih.gov/pubmed/32999239
http://dx.doi.org/10.2169/internalmedicine.5722-20
Descripción
Sumario:A 28-year-old woman was admitted during the eighth week of her pregnancy because her clinical course was consistent with rapid progressive glomerulonephritis (RPGN). Anti-glomerular basement membrane antibody (anti-GBM Ab) and myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) were positive, and the anti-GBM Ab titer being extremely high. She was treated with hemodialysis, plasma exchange and prednisolone. She survived the illness; however, neither the fetus nor her kidney function could be rescued. She had human leukocyte antigen (HLA)-DRB1*1502:01, which differs from the DRB1*1501 associated with anti-GBM GN. When patients have particular symptoms, we should check the urine and serum creatinine to exclude RPGN, even in cases of pregnancy.

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