Improvement of Skeletal Muscle Mass after Ledipasvir and Sofosbuvir Treatment for Hepatitis C Virus in Decompensated Liver Cirrhosis

Hepatitis C virus (HCV) can be eliminated by direct-acting antivirals in patients with decompensated liver cirrhosis. Although viral clearance in decompensated liver cirrhosis leads to improvement of the liver function and quality of life, changes in the skeletal muscle mass after sustained virologi...

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Autores principales: Sakamori, Ryotaro, Yamada, Ryoko, Shinkai, Kazuma, Doi, Akira, Tahata, Yuki, Shigekawa, Minoru, Kodama, Takahiro, Hikita, Hayato, Yamada, Tomomi, Tatsumi, Tomohide, Takehara, Tetsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990635/
https://www.ncbi.nlm.nih.gov/pubmed/33642562
http://dx.doi.org/10.2169/internalmedicine.6029-20
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author Sakamori, Ryotaro
Yamada, Ryoko
Shinkai, Kazuma
Doi, Akira
Tahata, Yuki
Shigekawa, Minoru
Kodama, Takahiro
Hikita, Hayato
Yamada, Tomomi
Tatsumi, Tomohide
Takehara, Tetsuo
author_facet Sakamori, Ryotaro
Yamada, Ryoko
Shinkai, Kazuma
Doi, Akira
Tahata, Yuki
Shigekawa, Minoru
Kodama, Takahiro
Hikita, Hayato
Yamada, Tomomi
Tatsumi, Tomohide
Takehara, Tetsuo
author_sort Sakamori, Ryotaro
collection PubMed
description Hepatitis C virus (HCV) can be eliminated by direct-acting antivirals in patients with decompensated liver cirrhosis. Although viral clearance in decompensated liver cirrhosis leads to improvement of the liver function and quality of life, changes in the skeletal muscle mass after sustained virologic response (SVR) in patients with decompensated liver cirrhosis have not been reported. We present the first report of skeletal muscle mass improvement with the achievement of SVR for HCV in a 76-year-old woman with decompensated liver cirrhosis. After achieving SVR through ledipasvir/sofosbuvir treatment, the patient showed an improvement in her liver function and an increase in her skeletal muscle mass.
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spelling pubmed-79906352021-03-29 Improvement of Skeletal Muscle Mass after Ledipasvir and Sofosbuvir Treatment for Hepatitis C Virus in Decompensated Liver Cirrhosis Sakamori, Ryotaro Yamada, Ryoko Shinkai, Kazuma Doi, Akira Tahata, Yuki Shigekawa, Minoru Kodama, Takahiro Hikita, Hayato Yamada, Tomomi Tatsumi, Tomohide Takehara, Tetsuo Intern Med Case Report Hepatitis C virus (HCV) can be eliminated by direct-acting antivirals in patients with decompensated liver cirrhosis. Although viral clearance in decompensated liver cirrhosis leads to improvement of the liver function and quality of life, changes in the skeletal muscle mass after sustained virologic response (SVR) in patients with decompensated liver cirrhosis have not been reported. We present the first report of skeletal muscle mass improvement with the achievement of SVR for HCV in a 76-year-old woman with decompensated liver cirrhosis. After achieving SVR through ledipasvir/sofosbuvir treatment, the patient showed an improvement in her liver function and an increase in her skeletal muscle mass. The Japanese Society of Internal Medicine 2021-03-01 2021-03-01 /pmc/articles/PMC7990635/ /pubmed/33642562 http://dx.doi.org/10.2169/internalmedicine.6029-20 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Sakamori, Ryotaro
Yamada, Ryoko
Shinkai, Kazuma
Doi, Akira
Tahata, Yuki
Shigekawa, Minoru
Kodama, Takahiro
Hikita, Hayato
Yamada, Tomomi
Tatsumi, Tomohide
Takehara, Tetsuo
Improvement of Skeletal Muscle Mass after Ledipasvir and Sofosbuvir Treatment for Hepatitis C Virus in Decompensated Liver Cirrhosis
title Improvement of Skeletal Muscle Mass after Ledipasvir and Sofosbuvir Treatment for Hepatitis C Virus in Decompensated Liver Cirrhosis
title_full Improvement of Skeletal Muscle Mass after Ledipasvir and Sofosbuvir Treatment for Hepatitis C Virus in Decompensated Liver Cirrhosis
title_fullStr Improvement of Skeletal Muscle Mass after Ledipasvir and Sofosbuvir Treatment for Hepatitis C Virus in Decompensated Liver Cirrhosis
title_full_unstemmed Improvement of Skeletal Muscle Mass after Ledipasvir and Sofosbuvir Treatment for Hepatitis C Virus in Decompensated Liver Cirrhosis
title_short Improvement of Skeletal Muscle Mass after Ledipasvir and Sofosbuvir Treatment for Hepatitis C Virus in Decompensated Liver Cirrhosis
title_sort improvement of skeletal muscle mass after ledipasvir and sofosbuvir treatment for hepatitis c virus in decompensated liver cirrhosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990635/
https://www.ncbi.nlm.nih.gov/pubmed/33642562
http://dx.doi.org/10.2169/internalmedicine.6029-20
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