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Only One Protomer Is Active in the Dimer of SARS 3C-like Proteinase
The severe acute respiratory syndrome coronavirus 3C-like protease has been proposed to be a key target for structurally based drug design against SARS. The enzyme exists as a mixture of dimer and monomer, and only the dimer was considered to be active. In this report, we have investigated, using mo...
Autores principales: | Chen, Hao, Wei, Ping, Huang, Changkang, Tan, Lei, Liu, Ying, Lai, Luhua |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990651/ https://www.ncbi.nlm.nih.gov/pubmed/16565086 http://dx.doi.org/10.1074/jbc.M510745200 |
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