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Metabolic support of tumor-infiltrating regulatory T cells by lactic acid

Regulatory T (T(reg)) cells, vital for maintaining immune homeostasis, also represent a major barrier to cancer immunity, as the tumor microenvironment (TME) promotes T(reg) cell recruitment, differentiation, and activity(1,2). Tumor cells have deregulated metabolism leading to a metabolite-depleted...

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Detalles Bibliográficos
Autores principales:	Watson, McLane J., Vignali, Paolo D.A., Mullett, Steven J., Overacre-Delgoffe, Abigail E., Peralta, Ronal M., Grebinoski, Stephanie, Menk, Ashley V., Rittenhouse, Natalie L., DePeaux, Kristin, Whetstone, Ryan D., Vignali, Dario A. A., Hand, Timothy W., Poholek, Amanda C., Morrison, Brett M., Rothstein, Jeffrey D., Wendell, Stacy G., Delgoffe, Greg M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990682/ https://www.ncbi.nlm.nih.gov/pubmed/33589820 http://dx.doi.org/10.1038/s41586-020-03045-2

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