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Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance.

Many antibiotics inhibit bacterial growth by binding to the ribosome and interfering with protein biosynthesis. Macrolides represent one of the most successful classes of ribosome-targeting antibiotics. The main clinically-relevant mechanism of resistance to macrolides is dimethylation of the 23S rR...

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Detalles Bibliográficos
Autores principales:	Svetlov, Maxim S., Syroegin, Egor A., Aleksandrova, Elena V., Atkinson, Gemma C., Gregory, Steven T., Mankin, Alexander S., Polikanov, Yury S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990689/ https://www.ncbi.nlm.nih.gov/pubmed/33462493 http://dx.doi.org/10.1038/s41589-020-00715-0

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