Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake

TUG proteins bind and sequester GLUT4 glucose transporters intracellularly, and insulin stimulates TUG cleavage to translocate this GLUT4 to the cell surface and increase glucose uptake. This effect of insulin is independent of phosphatidylinositol-3-kinase, and its physiological relevance remains u...

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Detalles Bibliográficos
Autores principales: Habtemichael, Estifanos N., Li, Don T., Camporez, João Paulo, Westergaard, Xavier O., Sales, Chloe I., Liu, Xinran, López-Giráldez, Francesc, DeVries, Stephen G., Li, Hanbing, Ruiz, Diana M., Wang, Kenny Y., Sayal, Bhavesh S., Zapata, Sofia González, Dann, Pamela, Brown, Stacey N., Hirabara, Sandro, Vatner, Daniel F., Goedeke, Leigh, Philbrick, William, Shulman, Gerald I., Bogan, Jonathan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990718/
https://www.ncbi.nlm.nih.gov/pubmed/33686286
http://dx.doi.org/10.1038/s42255-021-00359-x

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