Role of Circular RNA in Kidney-Related Diseases

The kidney is vital in maintaining fluid, electrolyte, and acid–base balance. Kidney-related diseases, which are an increasing public health issue, can happen to people of any age and at any time. Circular RNAs (circRNAs) are endogenous RNA that are produced by selective RNA splicing and are involve...

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Detalles Bibliográficos
Autores principales: Chen, Xin-Tian, Li, Zhong-Wei, Zhao, Xue, Li, Min-Le, Hou, Ping-Fu, Chu, Su-Fang, Zheng, Jun-Nian, Bai, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990792/
https://www.ncbi.nlm.nih.gov/pubmed/33776764
http://dx.doi.org/10.3389/fphar.2021.615882
Descripción
Sumario:The kidney is vital in maintaining fluid, electrolyte, and acid–base balance. Kidney-related diseases, which are an increasing public health issue, can happen to people of any age and at any time. Circular RNAs (circRNAs) are endogenous RNA that are produced by selective RNA splicing and are involved in progression of various diseases. Studies have shown that various kidney diseases, including renal cell carcinoma, acute kidney injury, and chronic kidney disease, are linked to circRNAs. This review outlines the characteristics and biological functions of circRNAs and discusses specific studies that provide insights into the function and potential of circRNAs for application in the diagnosis and treatment of kidney-related diseases.

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