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High KIFC1 expression is associated with poor prognosis in prostate cancer
Kinesins play important roles in the progression and development of cancer. Kinesin family member C1 (KIFC1), a minus end-directed motor protein, is a novel Kinesin involved in the clustering of excess centrosomes found in cancer cells. Recently KIFC1 has shown to play a role in the progression of m...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990808/ https://www.ncbi.nlm.nih.gov/pubmed/33760984 http://dx.doi.org/10.1007/s12032-021-01494-x |
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author | Kostecka, Laurie G. Olseen, Athen Kang, KiChang Torga, Gonzalo Pienta, Kenneth J. Amend, Sarah R. |
author_facet | Kostecka, Laurie G. Olseen, Athen Kang, KiChang Torga, Gonzalo Pienta, Kenneth J. Amend, Sarah R. |
author_sort | Kostecka, Laurie G. |
collection | PubMed |
description | Kinesins play important roles in the progression and development of cancer. Kinesin family member C1 (KIFC1), a minus end-directed motor protein, is a novel Kinesin involved in the clustering of excess centrosomes found in cancer cells. Recently KIFC1 has shown to play a role in the progression of many different cancers, however, the involvement of KIFC1 in the progression of prostate cancer (PCa) is still not well understood. This study investigated the expression and clinical significance of KIFC1 in PCa by utilizing multiple publicly available datasets to analyze KIFC1 expression in patient samples. High KIFC1 expression was found to be associated with high Gleason score, high tumor stage, metastatic lesions, high ploidy levels, and lower recurrence-free survival. These results reveal that high KIFC1 levels are associated with a poor prognosis for PCa patients and could act as a prognostic indicator for PCa patients as well. |
format | Online Article Text |
id | pubmed-7990808 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-79908082021-04-12 High KIFC1 expression is associated with poor prognosis in prostate cancer Kostecka, Laurie G. Olseen, Athen Kang, KiChang Torga, Gonzalo Pienta, Kenneth J. Amend, Sarah R. Med Oncol Original Paper Kinesins play important roles in the progression and development of cancer. Kinesin family member C1 (KIFC1), a minus end-directed motor protein, is a novel Kinesin involved in the clustering of excess centrosomes found in cancer cells. Recently KIFC1 has shown to play a role in the progression of many different cancers, however, the involvement of KIFC1 in the progression of prostate cancer (PCa) is still not well understood. This study investigated the expression and clinical significance of KIFC1 in PCa by utilizing multiple publicly available datasets to analyze KIFC1 expression in patient samples. High KIFC1 expression was found to be associated with high Gleason score, high tumor stage, metastatic lesions, high ploidy levels, and lower recurrence-free survival. These results reveal that high KIFC1 levels are associated with a poor prognosis for PCa patients and could act as a prognostic indicator for PCa patients as well. Springer US 2021-03-24 2021 /pmc/articles/PMC7990808/ /pubmed/33760984 http://dx.doi.org/10.1007/s12032-021-01494-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Paper Kostecka, Laurie G. Olseen, Athen Kang, KiChang Torga, Gonzalo Pienta, Kenneth J. Amend, Sarah R. High KIFC1 expression is associated with poor prognosis in prostate cancer |
title | High KIFC1 expression is associated with poor prognosis in prostate cancer |
title_full | High KIFC1 expression is associated with poor prognosis in prostate cancer |
title_fullStr | High KIFC1 expression is associated with poor prognosis in prostate cancer |
title_full_unstemmed | High KIFC1 expression is associated with poor prognosis in prostate cancer |
title_short | High KIFC1 expression is associated with poor prognosis in prostate cancer |
title_sort | high kifc1 expression is associated with poor prognosis in prostate cancer |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990808/ https://www.ncbi.nlm.nih.gov/pubmed/33760984 http://dx.doi.org/10.1007/s12032-021-01494-x |
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