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Roles of Non-Coding RNAs in Cervical Cancer Metastasis
Metastasis remains to be a huge challenge in cancer therapy. The mechanism underlying cervical cancer metastasis is not well understood and needs to be elucidated. Recent studies have highlighted the diverse roles of non-coding RNAs in cancer progression and metastasis. Increasing numbers of miRNAs,...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990873/ https://www.ncbi.nlm.nih.gov/pubmed/33777808 http://dx.doi.org/10.3389/fonc.2021.646192 |
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author | Cheng, Tanchun Huang, Shouguo |
author_facet | Cheng, Tanchun Huang, Shouguo |
author_sort | Cheng, Tanchun |
collection | PubMed |
description | Metastasis remains to be a huge challenge in cancer therapy. The mechanism underlying cervical cancer metastasis is not well understood and needs to be elucidated. Recent studies have highlighted the diverse roles of non-coding RNAs in cancer progression and metastasis. Increasing numbers of miRNAs, lncRNAs and circRNAs are found to be dysregulated in cervical cancer, associated with metastasis. They have been shown to regulate metastasis through regulating metastasis-related genes, epithelial-mesenchymal transition, signaling pathways and interactions with tumor microenvironment. Moreover, miRNAs can interact with lncRNAs and circRNAs respectively during this complex process. Herein, we review literatures up to date involving non-coding RNAs in cervical cancer metastasis, mainly focus on the underlying mechanisms and highlight the interaction network between miRNAs and lncRNAs, as well as circRNAs. Finally, we discuss the therapeutic prospects. |
format | Online Article Text |
id | pubmed-7990873 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79908732021-03-26 Roles of Non-Coding RNAs in Cervical Cancer Metastasis Cheng, Tanchun Huang, Shouguo Front Oncol Oncology Metastasis remains to be a huge challenge in cancer therapy. The mechanism underlying cervical cancer metastasis is not well understood and needs to be elucidated. Recent studies have highlighted the diverse roles of non-coding RNAs in cancer progression and metastasis. Increasing numbers of miRNAs, lncRNAs and circRNAs are found to be dysregulated in cervical cancer, associated with metastasis. They have been shown to regulate metastasis through regulating metastasis-related genes, epithelial-mesenchymal transition, signaling pathways and interactions with tumor microenvironment. Moreover, miRNAs can interact with lncRNAs and circRNAs respectively during this complex process. Herein, we review literatures up to date involving non-coding RNAs in cervical cancer metastasis, mainly focus on the underlying mechanisms and highlight the interaction network between miRNAs and lncRNAs, as well as circRNAs. Finally, we discuss the therapeutic prospects. Frontiers Media S.A. 2021-03-11 /pmc/articles/PMC7990873/ /pubmed/33777808 http://dx.doi.org/10.3389/fonc.2021.646192 Text en Copyright © 2021 Cheng and Huang http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Cheng, Tanchun Huang, Shouguo Roles of Non-Coding RNAs in Cervical Cancer Metastasis |
title | Roles of Non-Coding RNAs in Cervical Cancer Metastasis |
title_full | Roles of Non-Coding RNAs in Cervical Cancer Metastasis |
title_fullStr | Roles of Non-Coding RNAs in Cervical Cancer Metastasis |
title_full_unstemmed | Roles of Non-Coding RNAs in Cervical Cancer Metastasis |
title_short | Roles of Non-Coding RNAs in Cervical Cancer Metastasis |
title_sort | roles of non-coding rnas in cervical cancer metastasis |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990873/ https://www.ncbi.nlm.nih.gov/pubmed/33777808 http://dx.doi.org/10.3389/fonc.2021.646192 |
work_keys_str_mv | AT chengtanchun rolesofnoncodingrnasincervicalcancermetastasis AT huangshouguo rolesofnoncodingrnasincervicalcancermetastasis |