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Previous History of American Tegumentary Leishmaniasis Alters Susceptibility and Immune Response Against Schistosoma mansoni Infection in Humans

Schistosomiasis and Leishmaniasis are chronic parasitic diseases with high prevalence in some tropical regions and, due to their wide distribution, a risk of co-infections is present in some areas. Nevertheless, the impact of this interaction on human populations is still poorly understood. Thus, th...

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Autores principales: Miranda, Guilherme Silva, Resende, Samira Diniz, Cardoso, Diogo Tavares, Camelo, Genil Mororó Araújo, Silva, Jeferson Kelvin Alves Oliveira, de Castro, Vanessa Normandio, Geiger, Stefan Michael, Carneiro, Mariângela, Negrão-Corrêa, Deborah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990892/
https://www.ncbi.nlm.nih.gov/pubmed/33777015
http://dx.doi.org/10.3389/fimmu.2021.630934
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author Miranda, Guilherme Silva
Resende, Samira Diniz
Cardoso, Diogo Tavares
Camelo, Genil Mororó Araújo
Silva, Jeferson Kelvin Alves Oliveira
de Castro, Vanessa Normandio
Geiger, Stefan Michael
Carneiro, Mariângela
Negrão-Corrêa, Deborah
author_facet Miranda, Guilherme Silva
Resende, Samira Diniz
Cardoso, Diogo Tavares
Camelo, Genil Mororó Araújo
Silva, Jeferson Kelvin Alves Oliveira
de Castro, Vanessa Normandio
Geiger, Stefan Michael
Carneiro, Mariângela
Negrão-Corrêa, Deborah
author_sort Miranda, Guilherme Silva
collection PubMed
description Schistosomiasis and Leishmaniasis are chronic parasitic diseases with high prevalence in some tropical regions and, due to their wide distribution, a risk of co-infections is present in some areas. Nevertheless, the impact of this interaction on human populations is still poorly understood. Thus, the current study evaluated the effect of previous American Tegumentary Leishmaniasis (ATL) on the susceptibility and immune response to Schistosoma mansoni infection in residents from a rural community in Northern of Minas Gerais state, Brazil, an area endemic for both parasitic infections. The participants answered a socioeconomic questionnaire and provided stool and blood samples for parasitological and immunological evaluations. Stool samples were examined by a combination of parasitological techniques to identify helminth infections, especially S. mansoni eggs. Blood samples were used for hemograms and to measure the serum levels of cytokines and chemokines. Reports on previous ATL were obtained through interviews, clinical evaluation forms, and medical records. S. mansoni infection was the most prevalent parasitic infection in the study population (46%), and the majority of the infected individuals had a very low parasite burden. In the same population, 93 individuals (36.2%) reported previous ATL, and the prevalence of S. mansoni infection among these individuals was significantly higher than among individuals with no ATL history. A multiple logistic regression model revealed that S. mansoni infection was positively associated with higher levels of CCL3 and CCL17, and a higher frequency of IL-17 responders. Moreover, this model demonstrated that individuals with an ATL history had a 2-fold higher probability to be infected with S. mansoni (OR = 2.0; 95% CI 1.04–3.68). Among S. mansoni-infected individuals, the logistic regression demonstrated that a previous ATL history was negatively associated with the frequency of IL-17 responders and CXCL10 higher responders, but positively associated with higher IL-27 responders. Altogether, our data suggest that previous ATL may alter the susceptibility and the immune response in S. mansoni-infected individuals, which may likely affect the outcome of schistosomiasis and the severity of the disease in humans.
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spelling pubmed-79908922021-03-26 Previous History of American Tegumentary Leishmaniasis Alters Susceptibility and Immune Response Against Schistosoma mansoni Infection in Humans Miranda, Guilherme Silva Resende, Samira Diniz Cardoso, Diogo Tavares Camelo, Genil Mororó Araújo Silva, Jeferson Kelvin Alves Oliveira de Castro, Vanessa Normandio Geiger, Stefan Michael Carneiro, Mariângela Negrão-Corrêa, Deborah Front Immunol Immunology Schistosomiasis and Leishmaniasis are chronic parasitic diseases with high prevalence in some tropical regions and, due to their wide distribution, a risk of co-infections is present in some areas. Nevertheless, the impact of this interaction on human populations is still poorly understood. Thus, the current study evaluated the effect of previous American Tegumentary Leishmaniasis (ATL) on the susceptibility and immune response to Schistosoma mansoni infection in residents from a rural community in Northern of Minas Gerais state, Brazil, an area endemic for both parasitic infections. The participants answered a socioeconomic questionnaire and provided stool and blood samples for parasitological and immunological evaluations. Stool samples were examined by a combination of parasitological techniques to identify helminth infections, especially S. mansoni eggs. Blood samples were used for hemograms and to measure the serum levels of cytokines and chemokines. Reports on previous ATL were obtained through interviews, clinical evaluation forms, and medical records. S. mansoni infection was the most prevalent parasitic infection in the study population (46%), and the majority of the infected individuals had a very low parasite burden. In the same population, 93 individuals (36.2%) reported previous ATL, and the prevalence of S. mansoni infection among these individuals was significantly higher than among individuals with no ATL history. A multiple logistic regression model revealed that S. mansoni infection was positively associated with higher levels of CCL3 and CCL17, and a higher frequency of IL-17 responders. Moreover, this model demonstrated that individuals with an ATL history had a 2-fold higher probability to be infected with S. mansoni (OR = 2.0; 95% CI 1.04–3.68). Among S. mansoni-infected individuals, the logistic regression demonstrated that a previous ATL history was negatively associated with the frequency of IL-17 responders and CXCL10 higher responders, but positively associated with higher IL-27 responders. Altogether, our data suggest that previous ATL may alter the susceptibility and the immune response in S. mansoni-infected individuals, which may likely affect the outcome of schistosomiasis and the severity of the disease in humans. Frontiers Media S.A. 2021-03-11 /pmc/articles/PMC7990892/ /pubmed/33777015 http://dx.doi.org/10.3389/fimmu.2021.630934 Text en Copyright © 2021 Miranda, Resende, Cardoso, Camelo, Silva, Castro, Geiger, Carneiro and Negrão-Corrêa. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Miranda, Guilherme Silva
Resende, Samira Diniz
Cardoso, Diogo Tavares
Camelo, Genil Mororó Araújo
Silva, Jeferson Kelvin Alves Oliveira
de Castro, Vanessa Normandio
Geiger, Stefan Michael
Carneiro, Mariângela
Negrão-Corrêa, Deborah
Previous History of American Tegumentary Leishmaniasis Alters Susceptibility and Immune Response Against Schistosoma mansoni Infection in Humans
title Previous History of American Tegumentary Leishmaniasis Alters Susceptibility and Immune Response Against Schistosoma mansoni Infection in Humans
title_full Previous History of American Tegumentary Leishmaniasis Alters Susceptibility and Immune Response Against Schistosoma mansoni Infection in Humans
title_fullStr Previous History of American Tegumentary Leishmaniasis Alters Susceptibility and Immune Response Against Schistosoma mansoni Infection in Humans
title_full_unstemmed Previous History of American Tegumentary Leishmaniasis Alters Susceptibility and Immune Response Against Schistosoma mansoni Infection in Humans
title_short Previous History of American Tegumentary Leishmaniasis Alters Susceptibility and Immune Response Against Schistosoma mansoni Infection in Humans
title_sort previous history of american tegumentary leishmaniasis alters susceptibility and immune response against schistosoma mansoni infection in humans
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990892/
https://www.ncbi.nlm.nih.gov/pubmed/33777015
http://dx.doi.org/10.3389/fimmu.2021.630934
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