Cargando…

Design of Beam Shaping Assemblies for Accelerator-Based BNCT With Multi-Terminals

To moderate fast neutrons produced by accelerator to appropriate therapeutic energies for boron neutron capture therapy (BNCT), beam shaping assembly (BSA) is required definitely. In this work, based on a model of 2.5 MeV/30 mA proton accelerator, the Monte Carlo simulation software MCNPX was employ...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Guangru, Jiang, Wei, Zhang, Lu, Chen, Weiqiang, Li, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7991290/
https://www.ncbi.nlm.nih.gov/pubmed/33777888
http://dx.doi.org/10.3389/fpubh.2021.642561
_version_ 1783669192203960320
author Li, Guangru
Jiang, Wei
Zhang, Lu
Chen, Weiqiang
Li, Qiang
author_facet Li, Guangru
Jiang, Wei
Zhang, Lu
Chen, Weiqiang
Li, Qiang
author_sort Li, Guangru
collection PubMed
description To moderate fast neutrons produced by accelerator to appropriate therapeutic energies for boron neutron capture therapy (BNCT), beam shaping assembly (BSA) is required definitely. In this work, based on a model of 2.5 MeV/30 mA proton accelerator, the Monte Carlo simulation software MCNPX was employed to design multi-terminal BSAs. All parameters for both the thermal and epithermal neutron beams at the exit ports of the designed BSAs meet the treatment recommendation values proposed by the International Atomic Energy Agency (IAEA). The clinical parameters of the thermal and epithermal neutron beams were also calculated for clinical indication consideration.
format Online
Article
Text
id pubmed-7991290
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-79912902021-03-26 Design of Beam Shaping Assemblies for Accelerator-Based BNCT With Multi-Terminals Li, Guangru Jiang, Wei Zhang, Lu Chen, Weiqiang Li, Qiang Front Public Health Public Health To moderate fast neutrons produced by accelerator to appropriate therapeutic energies for boron neutron capture therapy (BNCT), beam shaping assembly (BSA) is required definitely. In this work, based on a model of 2.5 MeV/30 mA proton accelerator, the Monte Carlo simulation software MCNPX was employed to design multi-terminal BSAs. All parameters for both the thermal and epithermal neutron beams at the exit ports of the designed BSAs meet the treatment recommendation values proposed by the International Atomic Energy Agency (IAEA). The clinical parameters of the thermal and epithermal neutron beams were also calculated for clinical indication consideration. Frontiers Media S.A. 2021-03-11 /pmc/articles/PMC7991290/ /pubmed/33777888 http://dx.doi.org/10.3389/fpubh.2021.642561 Text en Copyright © 2021 Li, Jiang, Zhang, Chen and Li. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Li, Guangru
Jiang, Wei
Zhang, Lu
Chen, Weiqiang
Li, Qiang
Design of Beam Shaping Assemblies for Accelerator-Based BNCT With Multi-Terminals
title Design of Beam Shaping Assemblies for Accelerator-Based BNCT With Multi-Terminals
title_full Design of Beam Shaping Assemblies for Accelerator-Based BNCT With Multi-Terminals
title_fullStr Design of Beam Shaping Assemblies for Accelerator-Based BNCT With Multi-Terminals
title_full_unstemmed Design of Beam Shaping Assemblies for Accelerator-Based BNCT With Multi-Terminals
title_short Design of Beam Shaping Assemblies for Accelerator-Based BNCT With Multi-Terminals
title_sort design of beam shaping assemblies for accelerator-based bnct with multi-terminals
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7991290/
https://www.ncbi.nlm.nih.gov/pubmed/33777888
http://dx.doi.org/10.3389/fpubh.2021.642561
work_keys_str_mv AT liguangru designofbeamshapingassembliesforacceleratorbasedbnctwithmultiterminals
AT jiangwei designofbeamshapingassembliesforacceleratorbasedbnctwithmultiterminals
AT zhanglu designofbeamshapingassembliesforacceleratorbasedbnctwithmultiterminals
AT chenweiqiang designofbeamshapingassembliesforacceleratorbasedbnctwithmultiterminals
AT liqiang designofbeamshapingassembliesforacceleratorbasedbnctwithmultiterminals