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Self-buffering capacity of a human sulfatase for central nervous system delivery

Direct delivery of therapeutic enzymes to the Central Nervous System requires stringent formulation design. Not only should the formulation design consider the delicate balance of existing ions, proteins, and osmolality in the cerebrospinal fluid, it must also provide long term efficacy and stabilit...

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Detalles Bibliográficos
Autores principales:	Wen, Yi, Salamat-Miller, Nazila, Jain, Keethkumar, Taylor, Katherine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7991414/ https://www.ncbi.nlm.nih.gov/pubmed/33762621 http://dx.doi.org/10.1038/s41598-021-86178-2

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