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The incorporation loci of H3.3K36M determine its preferential prevalence in chondroblastomas
The histone H3.3K36M mutation, identified in over 90% of chondroblastoma cases, reprograms the H3K36 methylation landscape and gene expression to promote tumorigenesis. However, it’s still unclear how the H3K36M mutation preferentially occurs in the histone H3 variant H3.3 in chondroblastomas. Here,...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7991640/ https://www.ncbi.nlm.nih.gov/pubmed/33762579 http://dx.doi.org/10.1038/s41419-021-03597-9 |